Biomechanical changes following corneal crosslinking in keratoconus patients.

IF 2.4 3区 医学 Q2 OPHTHALMOLOGY
Emilia Felter, Ramin Khoramnia, Maximilian Friedrich, Hyeck-Soo Son, Gerd U Auffarth, Victor A Augustin
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引用次数: 0

Abstract

Purpose: To evaluate the biomechanical and tomographic outcomes of keratoconus patients up to four years after corneal crosslinking (CXL).

Methods: In this longitudinal retrospective-prospective single-center case series, the preoperative tomographic and biomechanical results from 200 keratoconus eyes of 161 patients undergoing CXL were compared to follow-up examinations at three-months, six-months, one-year, two-years, three-years, and four-years after CXL. Primary outcomes included the Corvis Biomechanical Factor (CBiF) and five biomechanical response parameters obtained from the Corvis ST. Tomographically, the Belin-Ambrósio deviation index (BAD-D) and the maximal keratometry (Kmax) measured by the Pentacam were analyzed. Additionally, Corvis E-staging, the thinnest corneal thickness (TCT), and the best-corrected visual acuity (BCVA) were obtained. Primary outcomes were compared using a paired t-test.

Results: The CBiF decreased significantly at the six-month (p < 0.001) and one-year (p < 0.001) follow-ups when compared to preoperative values. E-staging behaved accordingly to the CBiF. Within the two- to four-year follow-ups, the biomechanical outcomes showed no significant differences when compared to preoperative. Tomographically, the BAD-D increased significantly during the first year after CXL with a maximum at six-months (p < 0.001), while Kmax decreased significantly (p < 0.001) and continuously up to four years after CXL. The TCT was lower at all postoperative follow-up visits compared to preoperative, and the BCVA improved.

Conclusion: In the first year after CXL, there was a temporary progression in both the biomechanical CBiF and E-staging, as well as in the tomographic analysis. CXL contributes to the stabilization of both the tomographic and biomechanical properties of the cornea up to four years postoperatively.

Abstract Image

角膜交联术后角膜患者的生物力学变化。
目的:评估角膜交联术(CXL)后四年内角膜病患者的生物力学和断层扫描结果:在这一纵向回顾性-前瞻性单中心病例系列研究中,对 161 名接受 CXL 的患者的 200 只角膜塑形术眼的术前断层扫描和生物力学结果与 CXL 术后三个月、六个月、一年、两年、三年和四年的随访检查结果进行了比较。主要结果包括Corvis生物力学因子(CBiF)和从Corvis ST获得的五个生物力学响应参数。在断层扫描方面,分析了贝林-安布罗西奥偏差指数(BAD-D)和 Pentacam 测量的最大角膜度数(Kmax)。此外,还获得了 Corvis E 分期、最薄角膜厚度 (TCT) 和最佳矫正视力 (BCVA)。主要结果采用配对 t 检验进行比较:结果:CBiF 在六个月时明显下降(p 最大值明显下降(p 结论:CBiF 在六个月时明显下降(p 最大值明显下降(p 结论):CXL术后第一年,生物力学CBiF和E分期以及断层扫描分析均出现暂时性进展。术后四年内,CXL 有助于稳定角膜的层析和生物力学特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.40
自引率
7.40%
发文量
398
审稿时长
3 months
期刊介绍: Graefe''s Archive for Clinical and Experimental Ophthalmology is a distinguished international journal that presents original clinical reports and clini-cally relevant experimental studies. Founded in 1854 by Albrecht von Graefe to serve as a source of useful clinical information and a stimulus for discussion, the journal has published articles by leading ophthalmologists and vision research scientists for more than a century. With peer review by an international Editorial Board and prompt English-language publication, Graefe''s Archive provides rapid dissemination of clinical and clinically related experimental information.
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