Hybrid models to support development of fluid bed granulation processes

IF 4.5 2区工程技术 Q2 ENGINEERING, CHEMICAL

Powder Technology Pub Date : 2024-06-12 DOI:10.1016/j.powtec.2024.120005

Maksym Dosta, Ragna Hoffmann, Peter Schneider, Martin Maus

引用次数: 0

Abstract

The hybrid modeling strategy which is based on the integration of mechanistic and data-driven models is proposed and applied on fluidized bed granulation processes. The tight combination of empirical process knowledge by means of a mechanistic model and the multivariate data from PAT sensors allowed to gain benefits from both components. The hybrid strategy avoids any discrepancies between model and real process, increases transferability and general applicability of the model, as well as allows a smooth integration of Quality-by-Design principles for oral solid dosage forms.

In this contribution, two illustrative application examples for fluidized bed spray agglomeration and fluidized bed layering or coating processes are presented. It was shown that the proposed strategy can be successfully applied to support process development on different scales. It results in better process understanding, creation of regime maps and might end with the generation of a digital twin.

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支持流化床造粒工艺开发的混合模型

提出了基于机械模型和数据驱动模型整合的混合建模策略，并将其应用于流化床造粒过程。通过机械模型将经验工艺知识与来自 PAT 传感器的多变量数据紧密结合，可以从两个组成部分中获益。该混合策略避免了模型与实际工艺之间的任何差异，提高了模型的可移植性和普遍适用性，并使口服固体制剂的 "按质设计 "原则得以顺利整合。结果表明，所提出的策略可成功应用于支持不同规模的工艺开发。它可以更好地理解工艺过程，绘制工艺过程图，并最终生成数字孪生图。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Powder Technology 工程技术-工程：化工

CiteScore

9.90

自引率

15.40%

发文量

1047

审稿时长

46 days

期刊介绍： Powder Technology is an International Journal on the Science and Technology of Wet and Dry Particulate Systems. Powder Technology publishes papers on all aspects of the formation of particles and their characterisation and on the study of systems containing particulate solids. No limitation is imposed on the size of the particles, which may range from nanometre scale, as in pigments or aerosols, to that of mined or quarried materials. The following list of topics is not intended to be comprehensive, but rather to indicate typical subjects which fall within the scope of the journal's interests: Formation and synthesis of particles by precipitation and other methods. Modification of particles by agglomeration, coating, comminution and attrition. Characterisation of the size, shape, surface area, pore structure and strength of particles and agglomerates (including the origins and effects of inter particle forces). Packing, failure, flow and permeability of assemblies of particles. Particle-particle interactions and suspension rheology. Handling and processing operations such as slurry flow, fluidization, pneumatic conveying. Interactions between particles and their environment, including delivery of particulate products to the body. Applications of particle technology in production of pharmaceuticals, chemicals, foods, pigments, structural, and functional materials and in environmental and energy related matters. For materials-oriented contributions we are looking for articles revealing the effect of particle/powder characteristics (size, morphology and composition, in that order) on material performance or functionality and, ideally, comparison to any industrial standard.

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