The Blastulation Rate Is Negatively Associated With Euploid Rate

IF 2 Q2 OBSTETRICS & GYNECOLOGY

Journal of obstetrics and gynaecology Canada Pub Date : 2024-06-13 DOI:10.1016/j.jogc.2024.102586

Ido Feferkorn MD , Jason Raina MD , Eva Suarthana MD, PhD , Mohammad Albar MD , Asangla Ao PhD , Xiao Yun Zhang MSc , Li Zhang PhD , Einav Kadour-Peero MD , Ranit Hizkiyahu MD , Kimberly E. Liu MD , William M. Buckett MD

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引用次数: 0

Abstract

Objectives

To study the association between the blastulation rate, the presence of 1 pronucleus (1PN) zygotes, and the ploidy of the cohort of blastocysts.

Methods

A cross-sectional study using the existing databases of 2 university fertility centres in Canada. We included 345 cycles from 235 couples who underwent next-generation sequencing preimplantation genetic testing for the detection of aneuploidy in the study.

Results

A total of 1456 blastocysts were biopsied. In multivariate analysis, only female age and the number of 1PN/2PN embryos showed a negative association with euploid ratio. Surprisingly, when the analysis was limited to cycles with no delayed blastulation, the blastulation rate was also negatively associated with the euploid ratio.

Conclusions

This study sheds some light on the stages of early embryo development. Further study on the mechanisms governing embryo development and the different cell cycle checkpoints in embryo development is warranted.

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繁殖率与极性率呈负相关。

目的：研究囊胚形成率、1 个原核（1PN）合子的存在与囊胚群倍性之间的关联：利用加拿大两所大学生殖中心的现有数据库进行横断面研究。我们将 235 对接受新一代测序 PGT-A 的夫妇的 345 个周期纳入研究：结果：共对 1456 个囊胚进行了活检。在多变量分析中，只有女性的年龄和 1PN/2PN 胚胎的数量与优倍比呈负相关。令人惊讶的是，当分析仅限于没有延迟囊胚形成的周期时，囊胚形成率也与极体比率呈负相关：本研究揭示了早期胚胎发育的一些阶段。结论：本研究对早期胚胎发育阶段有一定的启示，需要进一步研究胚胎发育的机制和胚胎发育过程中不同的细胞周期检查点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of obstetrics and gynaecology Canada OBSTETRICS & GYNECOLOGY-

CiteScore

3.30

自引率

5.60%

发文量

302

审稿时长

32 days

期刊介绍： Journal of Obstetrics and Gynaecology Canada (JOGC) is Canada"s peer-reviewed journal of obstetrics, gynaecology, and women"s health. Each monthly issue contains original research articles, reviews, case reports, commentaries, and editorials on all aspects of reproductive health. JOGC is the original publication source of evidence-based clinical guidelines, committee opinions, and policy statements that derive from standing or ad hoc committees of the Society of Obstetricians and Gynaecologists of Canada. JOGC is included in the National Library of Medicine"s MEDLINE database, and abstracts from JOGC are accessible on PubMed.