Tas1R3 Dependent and Independent Recognition of Sugars in the Urethra and the Role of Tuft Cells in this Process (Adv. Biology 6/2024)

Abstract

Urinary Tract Infection

Increased sugar concentrations display risk factors for infections. Article number 2400117 by Klaus Deckmann and co-workers clarifies sugar monitoring in the urethra. Urethral tuft cells (UTC) are sentinels monitoring the urethral lumen and initiating protective mechanisms. Monitoring occurs via two pathways. A UTC/Tas1R3 dependent and a Tas1R3 independent pathway, found in both UTC and in other urethral epithelial cells. Sugars increases detrusor muscle activity UTC/Tas1R3 dependently.