Patricia Schmidt, Alexander Perniss, Martin Bodenbenner-Tuerich, Silke Wiegand, Loic Briand, Klaus Deckmann
{"title":"Tas1R3 Dependent and Independent Recognition of Sugars in the Urethra and the Role of Tuft Cells in this Process (Adv. Biology 6/2024)","authors":"Patricia Schmidt, Alexander Perniss, Martin Bodenbenner-Tuerich, Silke Wiegand, Loic Briand, Klaus Deckmann","doi":"10.1002/adbi.202470061","DOIUrl":null,"url":null,"abstract":"<p><b>Urinary Tract Infection</b></p><p>Increased sugar concentrations display risk factors for infections. Article number 2400117 by Klaus Deckmann and co-workers clarifies sugar monitoring in the urethra. Urethral tuft cells (UTC) are sentinels monitoring the urethral lumen and initiating protective mechanisms. Monitoring occurs via two pathways. A UTC/Tas1R3 dependent and a Tas1R3 independent pathway, found in both UTC and in other urethral epithelial cells. Sugars increases detrusor muscle activity UTC/Tas1R3 dependently.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adbi.202470061","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/adbi.202470061","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
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Abstract
Urinary Tract Infection
Increased sugar concentrations display risk factors for infections. Article number 2400117 by Klaus Deckmann and co-workers clarifies sugar monitoring in the urethra. Urethral tuft cells (UTC) are sentinels monitoring the urethral lumen and initiating protective mechanisms. Monitoring occurs via two pathways. A UTC/Tas1R3 dependent and a Tas1R3 independent pathway, found in both UTC and in other urethral epithelial cells. Sugars increases detrusor muscle activity UTC/Tas1R3 dependently.
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