Calcium hydroxyapatite @ polydopamine core-shell microspheres for photothermal regulation of human gingival fibroblast behavior

IF 4.7 3区材料科学 Q2 CHEMISTRY, PHYSICAL

Colloid and Interface Science Communications Pub Date : 2024-06-13 DOI:10.1016/j.colcom.2024.100792

Yijia Wang , Jiebing Zhang , Ning Ding, Ping Ma, Baijin Zeng

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Abstract

Gingival recession, a common oral problem, often results in functional complications and aesthetic imperfections. Calcium hydroxyapatite (HA) microspheres, known for their fibroblast-activating properties, have been used for facial tissue augmentation. The photothermal conversion effect, which uses near-infrared (NIR) light to generate mild thermal stimuli, has been shown to enhance cellular activity and accelerate wound healing. In the current study, core-shell structured calcium hydroxyapatite @ polydopamine (HA@PDA) microspheres with biocompatibility and photothermal efficacy were synthesized to improve the treatment of gingival recession. Cellular experiments demonstrated that the behavior of human gingival fibroblasts (HGFs) and the polarization of macrophages are modulated by HA@PDA microspheres through photothermal conversion under 808 nm NIR irradiation. The implications of these findings suggest that photothermal HA@PDA microspheres may serve as a promising modality for gingival augmentation, offering a safe, non-invasive, effective, and sustainable treatment strategy.

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用于光热调节人牙龈成纤维细胞行为的羟基磷灰石钙@聚多巴胺核壳微球

牙龈退缩是一种常见的口腔问题，通常会导致功能性并发症和美观缺陷。羟基磷灰石钙（HA）微球因其具有激活成纤维细胞的特性而闻名，已被用于面部组织增量。光热转换效应利用近红外（NIR）光产生温和的热刺激，已被证明能增强细胞活性并加速伤口愈合。本研究合成了具有生物相容性和光热效应的核壳结构羟基磷灰石钙@聚多巴胺（HA@PDA）微球，以改善牙龈退缩的治疗。细胞实验表明，在 808 纳米近红外照射下，HA@PDA 微球通过光热转换调节了人牙龈成纤维细胞（HGFs）的行为和巨噬细胞的极化。这些研究结果表明，光热HA@PDA微球可作为一种很有前景的牙龈增生方式，提供一种安全、无创、有效和可持续的治疗策略。

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来源期刊

Colloid and Interface Science Communications Materials Science-Materials Chemistry

CiteScore

9.40

自引率

6.70%

发文量

125

审稿时长

43 days

期刊介绍： Colloid and Interface Science Communications provides a forum for the highest visibility and rapid publication of short initial reports on new fundamental concepts, research findings, and topical applications at the forefront of the increasingly interdisciplinary area of colloid and interface science.