Major facilitator superfamily efflux pumps in human pathogens: Role in multidrug resistance and beyond

IF 4.8 Q1 MICROBIOLOGY

Current Research in Microbial Sciences Pub Date : 2024-01-01 DOI:10.1016/j.crmicr.2024.100248

Manjusha Lekshmi , Anely Ortiz-Alegria , Sanath Kumar , Manuel F. Varela

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Abstract

The major facilitator superfamily (MFS) of proteins constitutes a large group of related solute transporters found across all known living taxa of organisms. The transporters of the MFS contain an extremely diverse array of substrates, including ions, molecules of intermediary metabolism, and structurally different antimicrobial agents. First discovered over 30 years ago, the MFS represents an important collection of integral membrane transporters. Bacterial microorganisms expressing multidrug efflux pumps belonging to the MFS are considered serious pathogens, accounting for alarming morbidity and mortality numbers annually. This review article considers recent advances in the structure-function relationships, the transport mechanism, and modulation of MFS multidrug efflux pumps within the context of drug resistance mechanisms of bacterial pathogens of public health concerns.

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人类病原体中的主要促进剂超家族外排泵：多药耐药性及其他方面的作用

主要促进剂超家族蛋白质（MFS）是由一大群相关的溶质转运体组成的，这些转运体遍布所有已知的生物类群。MFS 的转运体含有极其多样的底物，包括离子、中间代谢分子和结构不同的抗菌剂。MFS 在 30 多年前首次被发现，代表了完整膜转运体的一个重要集合。表达属于 MFS 的多药外排泵的细菌微生物被认为是严重的病原体，每年造成的发病率和死亡率令人震惊。这篇综述文章结合公共卫生问题细菌病原体的耐药机制，探讨了 MFS 多药外排泵的结构-功能关系、转运机制和调控方面的最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Research in Microbial Sciences Immunology and Microbiology-Immunology and Microbiology (miscellaneous)

CiteScore

7.90

自引率

0.00%

发文量

审稿时长

66 days