Emerging trends in sperm selection: enhancing success rates in assisted reproduction.

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Xiang Zhang, Shuen Chao, Ningxin Ye, Dongfang Ouyang
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Abstract

This comprehensive review explores the evolving landscape of sperm selection techniques within the realm of Assisted Reproductive Technology (ART). Our analysis delves into a range of methods from traditional approaches like density gradient centrifugation to advanced techniques such as Magnetic-Activated Cell Sorting (MACS) and Intracytoplasmic Morphologically Selected Sperm Injection (IMSI). We critically assess the efficacy of these methods in terms of sperm motility, morphology, DNA integrity, and other functional attributes, providing a detailed comparison of their clinical outcomes. We highlight the transition from conventional sperm selection methods, which primarily focus on physical characteristics, to more sophisticated techniques that offer a comprehensive evaluation of sperm molecular properties. This shift not only promises enhanced prediction of fertilization success but also has significant implications for improving embryo quality and increasing the chances of live birth. By synthesizing various studies and research papers, we present an in-depth analysis of the predictability of different sperm selection procedures in ART. The review also discusses the clinical applicability of these methods, emphasizing their potential in shaping the future of assisted reproduction. Our findings suggest that the integration of advanced sperm selection strategies in ART could lead to more cost-effective treatments with reduced duration and higher success rates. This review aims to provide clinicians and researchers in reproductive medicine with comprehensive insights into the current state and future prospects of sperm selection technologies in ART.

精子选择的新趋势:提高辅助生殖的成功率。
这篇综合综述探讨了辅助生殖技术(ART)领域中精子选择技术的发展状况。我们的分析深入探讨了从密度梯度离心等传统方法到磁激活细胞分选(MACS)和卵胞浆内形态选择精子注射(IMSI)等先进技术的一系列方法。我们对这些方法在精子活力、形态、DNA完整性和其他功能属性方面的功效进行了严格评估,并对其临床结果进行了详细比较。我们强调了从主要关注物理特征的传统精子选择方法到提供精子分子特性综合评估的更先进技术的转变。这一转变不仅有望提高受精成功率的预测能力,而且对提高胚胎质量和增加活产几率具有重要意义。通过综合各种研究和研究论文,我们对 ART 中不同精子选择程序的可预测性进行了深入分析。综述还讨论了这些方法的临床适用性,强调了它们在塑造辅助生殖未来方面的潜力。我们的研究结果表明,在 ART 中整合先进的精子选择策略可使治疗更具成本效益,缩短疗程并提高成功率。本综述旨在为临床医生和生殖医学研究人员提供有关 ART 中精子选择技术的现状和未来前景的全面见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Reproductive Biology and Endocrinology
Reproductive Biology and Endocrinology 医学-内分泌学与代谢
CiteScore
7.90
自引率
2.30%
发文量
161
审稿时长
4-8 weeks
期刊介绍: Reproductive Biology and Endocrinology publishes and disseminates high-quality results from excellent research in the reproductive sciences. The journal publishes on topics covering gametogenesis, fertilization, early embryonic development, embryo-uterus interaction, reproductive development, pregnancy, uterine biology, endocrinology of reproduction, control of reproduction, reproductive immunology, neuroendocrinology, and veterinary and human reproductive medicine, including all vertebrate species.
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