Increased obesogenic action of palmitic acid during early stage of adipogenesis

IF 3.9 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Molecular and cell biology of lipids Pub Date : 2024-06-12 DOI:10.1016/j.bbalip.2024.159525

Ewa Stanek , Krzysztof Czamara , Agnieszka Kaczor

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引用次数: 0

Abstract

The functional differences between preadipocytes and fully differentiated mature adipocytes derived from stromal vascular fraction stem cells, as well as primary adipocytes have been analysed by evaluating their response to the obesogenic factor (a saturated fatty acid) and TNF-triggered inflammation. The analysis of single adipocytes shows that the saturated fatty acid (palmitic acid) accumulation is accompanied by inflammation and considerably dependent on the stage of the adipogenesis. In particular, preadipocytes show the exceptional potential for palmitic acid uptake resulting in their hypertrophy and the elevated cellular expression of the inflammation marker (ICAM-1). Our research provides new information on the impact of obesogenic factors on preadipocytes that is important in the light of childhood obesity prevention.

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在脂肪生成的早期阶段，棕榈酸会增加致肥作用。

通过评估前脂肪细胞和完全分化的成熟脂肪细胞对致肥因子（饱和脂肪酸）和 TNF 引发的炎症的反应，分析了它们之间的功能差异。对单个脂肪细胞的分析表明，饱和脂肪酸（棕榈酸）的积累伴随着炎症，并在很大程度上取决于脂肪生成的阶段。特别是，前脂肪细胞显示出摄取棕榈酸的特殊潜力，导致其肥大和炎症标志物（ICAM-1）的细胞表达升高。我们的研究提供了关于致胖因素对前脂肪细胞影响的新信息，这对预防儿童肥胖非常重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochimica et biophysica acta. Molecular and cell biology of lipids 生物-生化与分子生物学

CiteScore

11.00

自引率

2.10%

发文量

109

审稿时长

53 days

期刊介绍： BBA Molecular and Cell Biology of Lipids publishes papers on original research dealing with novel aspects of molecular genetics related to the lipidome, the biosynthesis of lipids, the role of lipids in cells and whole organisms, the regulation of lipid metabolism and function, and lipidomics in all organisms. Manuscripts should significantly advance the understanding of the molecular mechanisms underlying biological processes in which lipids are involved. Papers detailing novel methodology must report significant biochemical, molecular, or functional insight in the area of lipids.