S-cone contribution to oscillatory potentials in patients with blue cone monochromacy.

IF 2.6 4区医学 Q2 OPHTHALMOLOGY

Documenta Ophthalmologica Pub Date : 2024-08-01 Epub Date: 2024-06-14 DOI:10.1007/s10633-024-09981-y

Giulia Righetti, Melanie Kempf, Susanne Kohl, Bernd Wissinger, Laura Kühlewein, Katarina Stingl, Krunoslav Stingl

{"title":"S-cone contribution to oscillatory potentials in patients with blue cone monochromacy.","authors":"Giulia Righetti, Melanie Kempf, Susanne Kohl, Bernd Wissinger, Laura Kühlewein, Katarina Stingl, Krunoslav Stingl","doi":"10.1007/s10633-024-09981-y","DOIUrl":null,"url":null,"abstract":"Purpose: The aim of this exploratory study is to investigate the role of S-cones in oscillatory potentials (OPs) generation by individuals with blue-cone monochromacy (BCM), retaining S-cones, and achromatopsia (ACHM), lacking cone functions.Methods: This retrospective study analyzed data from 39 ACHM patients, 20 BCM patients, and 26 controls. Central foveal thickness was obtained using spectral-domain optical coherence tomography, while amplitude and implicit time (IT) of a- and b-waves were extracted from the ISCEV Standard dark-adapted 3 cd.s.m-2 full-field ERG (ffERG). Time-frequency analysis of the same measurement enabled the extraction of OPs, providing insights into the dynamic characteristics of the recorded signal.Results: Both ACHM and BCM groups showed a significant reduction (p < .00001) of a- and b-wave amplitudes and ITs as well as the power of the OPs compared to the control groups. The comparison between ACHM and BCM didn't show any statistically significant differences in the electrophysiological parameters. The analysis of covariance revealed significantly reduced central foveal thickness in the BCM group compared to ACHM and controls (p < .00001), and in ACHM compared to controls (p < .00001), after age correction and Tukey post-hoc analysis.Conclusions: S-cones do not significantly influence OPs, and the decline in OPs' power is not solely due to a reduced a-wave. This suggests a complex non-linear network influenced by photoreceptor inputs. Morphological changes don't correlate directly with functional alterations, prompting further exploration of OPs' function and physiological role.","PeriodicalId":11207,"journal":{"name":"Documenta Ophthalmologica","volume":" ","pages":"11-21"},"PeriodicalIF":2.6000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236933/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Documenta Ophthalmologica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10633-024-09981-y","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/14 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: The aim of this exploratory study is to investigate the role of S-cones in oscillatory potentials (OPs) generation by individuals with blue-cone monochromacy (BCM), retaining S-cones, and achromatopsia (ACHM), lacking cone functions.

Methods: This retrospective study analyzed data from 39 ACHM patients, 20 BCM patients, and 26 controls. Central foveal thickness was obtained using spectral-domain optical coherence tomography, while amplitude and implicit time (IT) of a- and b-waves were extracted from the ISCEV Standard dark-adapted 3 cd.s.m^-2 full-field ERG (ffERG). Time-frequency analysis of the same measurement enabled the extraction of OPs, providing insights into the dynamic characteristics of the recorded signal.

Results: Both ACHM and BCM groups showed a significant reduction (p < .00001) of a- and b-wave amplitudes and ITs as well as the power of the OPs compared to the control groups. The comparison between ACHM and BCM didn't show any statistically significant differences in the electrophysiological parameters. The analysis of covariance revealed significantly reduced central foveal thickness in the BCM group compared to ACHM and controls (p < .00001), and in ACHM compared to controls (p < .00001), after age correction and Tukey post-hoc analysis.

Conclusions: S-cones do not significantly influence OPs, and the decline in OPs' power is not solely due to a reduced a-wave. This suggests a complex non-linear network influenced by photoreceptor inputs. Morphological changes don't correlate directly with functional alterations, prompting further exploration of OPs' function and physiological role.

Abstract Image

查看原文本刊更多论文

蓝锥单色患者的 S 锥体对振荡电位的贡献。

目的：本探索性研究旨在调查 S 锥体在蓝锥体单色性（BCM）患者（保留 S 锥体）和消色差（ACHM）患者（缺乏锥体功能）产生振荡电位（OPs）中的作用：这项回顾性研究分析了 39 名 ACHM 患者、20 名 BCM 患者和 26 名对照组的数据。使用光谱域光学相干断层扫描获得了中心眼窝厚度，同时从ISCEV标准暗适应3 cd.s.m-2全视野ERG（ffERG）中提取了a波和b波的振幅和隐含时间（IT）。通过对同一测量结果进行时频分析，可以提取 OPs，从而了解记录信号的动态特性：结果：ACHM 组和 BCM 组的 OPs 均显著降低（p 结论：ACHM 组和 BCM 组的 OPs 均显著降低：S 音锥对 OPs 的影响不大，OPs 功率的下降并不完全是由于 a 波的减弱。这表明受光感受器输入影响的是一个复杂的非线性网络。形态变化与功能改变并不直接相关，这促使人们进一步探索 OPs 的功能和生理作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Documenta Ophthalmologica 医学-眼科学

CiteScore

3.50

自引率

21.40%

发文量

审稿时长

>12 weeks

期刊介绍： Documenta Ophthalmologica is an official publication of the International Society for Clinical Electrophysiology of Vision. The purpose of the journal is to promote the understanding and application of clinical electrophysiology of vision. Documenta Ophthalmologica will publish reviews, research articles, technical notes, brief reports and case studies which inform the readers about basic and clinical sciences related to visual electrodiagnosis and means to improve diagnosis and clinical management of patients using visual electrophysiology. Studies may involve animals or humans. In either case appropriate care must be taken to follow the Declaration of Helsinki for human subject or appropriate humane standards of animal care (e.g., the ARVO standards on Animal Care and Use).