Enhancer-promoter communication in Drosophila developmental gene transcription.

George Hunt, Mattias Mannervik
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Abstract

Enhancers play an essential role in gene regulation by receiving cues from transcription factors and relaying these signals to modulate transcription from target promoters. Enhancer-promoter communications occur across large linear distances of the genome and with high specificity. The molecular mechanisms that underlie enhancer-mediated control of transcription remain unresolved. In this review, we focus on research in Drosophila uncovering the molecular mechanisms governing enhancer-promoter communication and discuss the current understanding of developmental gene regulation. The functions of protein acetylation, pausing of RNA polymerase II, transcriptional bursting, and the formation of nuclear hubs in the induction of tissue-specific programs of transcription during zygotic genome activation are considered.

果蝇发育基因转录中的增强子-启动子通讯
增强子在基因调控中发挥着重要作用,它接收来自转录因子的信号,并将这些信号传递给靶启动子,从而调节靶启动子的转录。增强子与启动子之间的通讯跨越基因组的大线性距离,并具有高度特异性。增强子介导转录控制的分子机制仍未解决。在这篇综述中,我们将重点介绍果蝇研究揭示增强子-启动子通讯分子机制的情况,并讨论目前对发育基因调控的理解。文章探讨了蛋白质乙酰化、RNA聚合酶II的暂停、转录猝灭以及核枢纽的形成在子代基因组激活过程中诱导组织特异性转录程序的功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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