{"title":"The tumor-driven antibody-mediated immune response in cancer","authors":"","doi":"10.1016/j.coi.2024.102431","DOIUrl":null,"url":null,"abstract":"<div><p><span>Immune cells<span><span><span><span> in the tumor microenvironment play a crucial role in </span>cancer prognosis and response to </span>immunotherapy. Recent studies highlight the significance of tumor-infiltrating B cells and </span>tertiary lymphoid structures<span> as markers of favorable prognosis and patient-positive response to immune checkpoint<span> blockers in some types of cancer. Although the presence of germinal center B cells and plasma cells in the tumor microenvironment has been established, determining their tumor reactivity remains challenging. The few known tumor targets range from </span></span></span></span>viral proteins<span><span> to self and altered self-proteins. The emergence of self-reactive antibodies in patients with cancer, involves the opposing forces of antigen-driven affinity increase and peripheral tolerance mechanisms. Here, B cell </span>tumor antigen<span> specificity and affinity maturation in tumor-directed immune responses in cancer are discussed.</span></span></p></div>","PeriodicalId":11361,"journal":{"name":"Current Opinion in Immunology","volume":null,"pages":null},"PeriodicalIF":6.6000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Immunology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0952791524000219","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Immune cells in the tumor microenvironment play a crucial role in cancer prognosis and response to immunotherapy. Recent studies highlight the significance of tumor-infiltrating B cells and tertiary lymphoid structures as markers of favorable prognosis and patient-positive response to immune checkpoint blockers in some types of cancer. Although the presence of germinal center B cells and plasma cells in the tumor microenvironment has been established, determining their tumor reactivity remains challenging. The few known tumor targets range from viral proteins to self and altered self-proteins. The emergence of self-reactive antibodies in patients with cancer, involves the opposing forces of antigen-driven affinity increase and peripheral tolerance mechanisms. Here, B cell tumor antigen specificity and affinity maturation in tumor-directed immune responses in cancer are discussed.
肿瘤微环境中的免疫细胞在癌症预后和对免疫疗法的反应中起着至关重要的作用。最近的研究强调了肿瘤浸润 B 细胞和三级淋巴结构的重要性，它们是某些类型癌症预后良好和患者对免疫检查点阻断剂反应阳性的标志。虽然生殖中心 B 细胞和浆细胞在肿瘤微环境中的存在已被证实，但确定它们的肿瘤反应性仍具有挑战性。已知的少数肿瘤靶点包括病毒蛋白、自身蛋白和改变的自身蛋白。癌症患者体内自身反应性抗体的出现涉及抗原驱动的亲和力增强和外周耐受机制的对立力量。在此，我们将讨论B细胞肿瘤抗原特异性和亲和力成熟在肿瘤导向的癌症免疫反应中的作用。
期刊介绍：
Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed.
In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.
Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students.
Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.
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