Beyond the danger signal: RNA aggregates orchestrate immunotherapy.

IF 12.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in molecular medicine Pub Date : 2024-08-01 Epub Date: 2024-06-11 DOI:10.1016/j.molmed.2024.05.018

Quazi T H Shubhra, Tivadar Feczkó, Qiang Cai

引用次数: 0

Abstract

Mendez-Gomez et al. recently demonstrated the transformative potential of RNA-lipid particle aggregates (RNA-LPAs) in immunotherapy. By reprogramming the tumor microenvironment (TME) and potentiating antitumor immunity, RNA-LPAs target primary tumors and elicit robust systemic immunity. This innovative platform holds promise for translating preclinical success into tangible clinical benefits.

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超越危险信号：RNA 聚集体可协调免疫疗法。

门德斯-戈麦斯（Mendez-Gomez）等人最近证明了RNA-脂质颗粒聚集体（RNA-LPAs）在免疫疗法中的变革潜力。通过重编程肿瘤微环境（TME）和增强抗肿瘤免疫力，RNA-LPAs 可靶向原发性肿瘤并激发强大的全身免疫力。这一创新平台有望将临床前的成功转化为切实的临床效益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in molecular medicine 医学-生化与分子生物学

CiteScore

24.60

自引率

0.00%

发文量

142

审稿时长

6-12 weeks

期刊介绍： Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.