Current Management of Neuroendocrine Tumour Liver Metastases.

IF 4.7 2区 医学 Q1 ONCOLOGY
Current Oncology Reports Pub Date : 2024-09-01 Epub Date: 2024-06-13 DOI:10.1007/s11912-024-01559-w
Aditya Sharma, Mughilan Muralitharan, John Ramage, Dominique Clement, Krishna Menon, Parthi Srinivasan, Mohamed Elmasry, Nick Reed, Matthew Seager, Rajaventhan Srirajaskanthan
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Abstract

Purpose of review: This article aims to illustrate the current state of investigations and management of liver metastases in patients with Neuroendocrine Neoplasms. Neuroendocrine tumours (NETs) are rising in incidence globally and have become the second most prevalent gastrointestinal malignancy in UK and USA. Frequently, patients have metastatic disease at time of presentation. The liver is the most common site of metastases for gastro-enteropancreatic NETs. Characterisation of liver metastases with imaging is important to ensure disease is not under-staged.

Recent findings: Magnetic resonance imaging and positron emission tomography are now becoming standard of care for imaging liver metastases. There is an increasing armamentarium of therapies available for management of NETs and loco-regional therapy for liver metastases. The data supporting surgical and loco-regional therapy is reviewed with focus on role of liver transplantation. It is important to use appropriate imaging and classification of NET liver metastases. It is key that decisions regarding approach to treatment is undertaken in a multidisciplinary team and that individualised approaches are considered for management of patients with metastatic NETs.

Abstract Image

神经内分泌肿瘤肝转移的当前治疗方法。
综述目的:本文旨在说明神经内分泌肿瘤患者肝转移的调查和管理现状。神经内分泌肿瘤(NET)的发病率在全球呈上升趋势,在英国和美国已成为第二大胃肠道恶性肿瘤。患者通常在发病时已患有转移性疾病。肝脏是胃肠胰NET最常见的转移部位。肝转移的影像学特征对于确保疾病不被低估非常重要:磁共振成像和正电子发射断层扫描目前已成为肝转移瘤成像的标准方法。目前有越来越多的疗法可用于治疗母细胞瘤和肝转移瘤的局部区域治疗。本文回顾了支持手术和局部区域治疗的数据,并重点介绍了肝移植的作用。对NET肝转移瘤进行适当的成像和分类非常重要。关键是要由多学科团队共同决定治疗方法,并考虑对转移性NET患者进行个体化治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
8.50
自引率
0.00%
发文量
187
审稿时长
6-12 weeks
期刊介绍: This journal aims to review the most important, recently published clinical findings in the field of oncology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by cancer. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as cancer prevention, leukemia, melanoma, neuro-oncology, and palliative medicine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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