Targeting fatty acid synthase in preclinical models of TNBC brain metastases synergizes with SN-38 and impairs invasion.

IF 6.5 2区医学 Q1 ONCOLOGY

NPJ Breast Cancer Pub Date : 2024-06-10 DOI:10.1038/s41523-024-00656-0

Habib A Serhan, Liwei Bao, Xu Cheng, Zhaoping Qin, Chia-Jen Liu, Jason A Heth, Aaron M Udager, Matthew B Soellner, Sofia D Merajver, Aki Morikawa, Nathan M Merrill

引用次数: 0

Abstract

Fatty acid synthesis (FAS) has been shown to play a key role in the survival of brain-metastatic (BM) breast cancer. We demonstrate that the fatty acid synthase inhibitor TVB-2640 synergizes with the topoisomerase inhibitor SN-38 in triple-negative breast cancer (TNBC) BM cell lines, upregulates FAS and downregulates cell cycle progression gene expression, and slows the motility of TNBC BM cell lines. The combination of SN-38 and TVB-2640 warrants further consideration as a potential therapeutic option in TNBC BMs.

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在 TNBC 脑转移瘤临床前模型中靶向脂肪酸合成酶与 SN-38 协同作用，并能抑制侵袭。

脂肪酸合成（FAS）已被证明在脑转移（BM）乳腺癌的生存中起着关键作用。我们证明，脂肪酸合成酶抑制剂 TVB-2640 与拓扑异构酶抑制剂 SN-38 在三阴性乳腺癌（TNBC）脑转移细胞系中具有协同作用，能上调脂肪酸合成酶，下调细胞周期进展基因的表达，并减缓 TNBC 脑转移细胞系的运动。SN-38 和 TVB-2640 的组合作为 TNBC BM 的潜在治疗方案值得进一步考虑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Breast Cancer Medicine-Pharmacology (medical)

CiteScore

10.10

自引率

1.70%

发文量

122

审稿时长

9 weeks

期刊介绍： npj Breast Cancer publishes original research articles, reviews, brief correspondence, meeting reports, editorial summaries and hypothesis generating observations which could be unexplained or preliminary findings from experiments, novel ideas, or the framing of new questions that need to be solved. Featured topics of the journal include imaging, immunotherapy, molecular classification of disease, mechanism-based therapies largely targeting signal transduction pathways, carcinogenesis including hereditary susceptibility and molecular epidemiology, survivorship issues including long-term toxicities of treatment and secondary neoplasm occurrence, the biophysics of cancer, mechanisms of metastasis and their perturbation, and studies of the tumor microenvironment.