Characterization of blood inflammatory markers in patients with non-small cell lung cancer.

IF 1.1 Q4 ONCOLOGY
International journal of clinical and experimental pathology Pub Date : 2024-05-15 eCollection Date: 2024-01-01 DOI:10.62347/IPTW9741
Yinggang Zhai, Jinqiang Wu, Chunrong Tang, Binghua Huang, Qinyu Bi, Shiguan Luo
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引用次数: 0

Abstract

Objective: To investigate the differences and correlation between blood inflammatory indexes such as monocytes (MONO), lymphocytes (LYM), haemoglobin (HGB), neutrophils (NEU), platelets (PLT), ultrasensitive C-reactive protein, albumin and platelet/lymphocyte ratio (PLR), NEU/LYM ratio (NLR), MONO/LYM ratio (MLR) and clinicopathologic characteristics of patients with non-small cell lung cancer (NSCLC).

Methods: 187 patients with NSCLC who were first diagnosed in 2017-2023 and 102 with healthy check-ups during the same period (control group) were retrospectively selected as study subjects to compare the differences in inflammatory indexes between the two groups and the levels of inflammatory indexes in NSCLC patients with different clinicopathologic characteristics.

Results: Correlation analysis between blood inflammatory indexes and clinicopathologic features in NSCLC group showed that C-reactive protein, CAR, and PLR values were different in different pathologic types (P<0.05). The values of NEU, MONO, C-reactive protein, MLR, NLR, CAR and albumin were different among various degrees of differentiation (P<0.05). There were differences in LYM, albumin, MLR, NLR, CAR, and C-reactive protein among M stage subgroups (P<0.05). Analysis of the efficacy of early diagnosis of non-small cell lung cancer has been shown, the AUC of NLR was 0.796, sensitivity of 0.679, specificity of 0.176, 95% CI=0.743-0.849 (P<0.001). The AUC of albumin was 0.977, the sensitivity was 0.941, the specificity was 0.941, and 95% CI was 0.959-0.994 (P<0.001).

Conclusion: Blood inflammatory indexes are closely associated with NSCLC and vary according to pathologic features. Blood inflammatory indices can predict tumor pathologic staging and guide treatment for patients with NSCLC.

非小细胞肺癌患者血液炎症标志物的特征。
目的探讨单核细胞(MONO)、淋巴细胞(LYM)、血红蛋白(HGB)、中性粒细胞(NEU)、血小板(PLT)、超敏C反应蛋白、白蛋白及血小板/淋巴细胞比值(PLR)、NEU/LYM比值(NLR)、MONO/LYM比值(MLR)等血液炎症指标与非小细胞肺癌(NSCLC)患者临床病理特征的差异及相关性。方法:回顾性选取2017-2023年首次确诊的187例NSCLC患者和同期健康体检的102例患者(对照组)作为研究对象,比较两组患者炎症指标的差异以及不同临床病理特征的NSCLC患者炎症指标水平:结果:NSCLC组血液炎症指标与临床病理特征的相关性分析表明,C反应蛋白、CAR和PLR值在不同病理类型(PC结论:血液炎症指标与NSCLC的临床病理特征密切相关:血液炎症指标与 NSCLC 密切相关,并随病理特征的不同而变化。血液炎症指标可以预测肿瘤的病理分期并指导 NSCLC 患者的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
自引率
0.00%
发文量
42
审稿时长
1 months
期刊介绍: The International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) is a peer reviewed, open access online journal. It was founded in 2008 by an international group of academic pathologists and scientists who are devoted to the scientific exploration of human disease and the rapid dissemination of original data. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal.
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