Pyroptosis: A major trigger of excessive immune response in the gingiva.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-06-09 DOI:10.1111/odi.15013

Xueyu Xiang, Jing Zhang, Yuan Yue

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引用次数: 0

Abstract

Objectives: The gingival mucosal barrier, an important oral cavity barrier, plays a significant role in preventing pathogenic microorganism invasion and maintaining periodontal tissue health. Pathogenic microorganism invasion of the gingival mucosa produces a large number of cytokines. Among them, pyroptosis is an important player in exacerbating immune-inflammatory responses, leading to tissue destruction. However, the mechanism of pyroptosis and the immune response it triggers have not been fully elucidated. We provide an overview of recent advances in understanding gingival physical barrier pyroptosis and inflammation-induced hyperimmunity.

Methods: PubMed, Web of Science databases were searched for articles, reviews, and clinical studies published until March 2024.

Results: We summarised the importance of the gingival barrier in terms of the functions of different cells, described the progress in research on gingival epithelial cell and gingival fibroblast pyroptosis and the immune-inflammatory response it induces, and discussed the relationship between pyroptosis and systemic diseases, association of multiple cell death systems. Finally, we propose future directions for pyroptosis research.

Conclusions: Pyroptosis often triggers a range of inflammatory immune responses that lead to associated diseases. Therefore, further study of the molecular mechanisms of pyroptosis and the immune responses is warranted.

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火化病：牙龈过度免疫反应的主要诱因。

目的：牙龈粘膜屏障是重要的口腔屏障，在防止病原微生物入侵和维持牙周组织健康方面发挥着重要作用。病原微生物入侵牙龈粘膜会产生大量细胞因子。其中，脓毒症是加剧免疫炎症反应、导致组织破坏的重要因素。然而，热蛋白沉积的机制及其引发的免疫反应尚未完全阐明。我们将概述最近在了解牙龈物理屏障热渗透和炎症诱导的高免疫性方面取得的进展：方法：检索了 PubMed、Web of Science 数据库中截至 2024 年 3 月发表的文章、综述和临床研究：我们总结了牙龈屏障在不同细胞功能方面的重要性，描述了有关牙龈上皮细胞和牙龈成纤维细胞热解及其诱导的免疫炎症反应的研究进展，并讨论了热解与全身性疾病的关系、多种细胞死亡系统的关联。最后，我们提出了热核病研究的未来方向：热蛋白沉积通常会引发一系列炎症免疫反应，从而导致相关疾病。因此，有必要对火疽病和免疫反应的分子机制进行进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.