Parathyroid Gland Generation from Pluripotent Stem Cells.

IF 3.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Endocrinology and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-06-10 DOI:10.3803/EnM.2024.1989

Mayuko Kano

引用次数: 0

Abstract

Patients with permanent hypoparathyroidism require lifelong treatment. Current replacement therapies sometimes have adverse effects (e.g., hypercalciuria and chronic kidney disease). Generating parathyroid glands (PTGs) from the patient's own induced pluripotent stem cells (PSCs), with transplantation of these PTGs, would be an effective treatment option. Multiple methods for generating PTGs from PSCs have been reported. One major trend is in vitro differentiation of PSCs into PTGs. Another is in vivo generation of PSC-derived PTGs by injecting PSCs into PTG-deficient embryos. This review discusses current achievements and challenges in present and future PTG regenerative medicine.

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利用多能干细胞生成甲状旁腺

永久性甲状旁腺功能减退症患者需要终身治疗。目前的替代疗法有时会产生不良反应（如高钙血症和慢性肾病）。利用患者自身的诱导多能干细胞（PSCs）生成甲状旁腺（PTGs），并移植这些PTGs，将是一种有效的治疗方案。从多能干细胞生成PTG的方法有多种。一个主要趋势是在体外将造血干细胞分化成 PTG。另一种方法是将造血干细胞注射到 PTG 缺乏的胚胎中，在体内生成造血干细胞衍生的 PTG。本综述讨论了目前和未来PTG再生医学的成就和挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrinology and Metabolism Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

6.60

自引率

5.90%

发文量

145

审稿时长

24 weeks

期刊介绍： The aim of this journal is to set high standards of medical care by providing a forum for discussion for basic, clinical, and translational researchers and clinicians on new findings in the fields of endocrinology and metabolism. Endocrinology and Metabolism reports new findings and developments in all aspects of endocrinology and metabolism. The topics covered by this journal include bone and mineral metabolism, cytokines, developmental endocrinology, diagnostic endocrinology, endocrine research, dyslipidemia, endocrine regulation, genetic endocrinology, growth factors, hormone receptors, hormone action and regulation, management of endocrine diseases, clinical trials, epidemiology, molecular endocrinology, neuroendocrinology, neuropeptides, neurotransmitters, obesity, pediatric endocrinology, reproductive endocrinology, signal transduction, the anatomy and physiology of endocrine organs (i.e., the pituitary, thyroid, parathyroid, and adrenal glands, and the gonads), and endocrine diseases (diabetes, nutrition, osteoporosis, etc.).