Antibody responses to respiratory syncytial virus: a population-based cross-sectional serological study in Southern China, 2021

IF 10.9 1区 医学 Q1 INFECTIOUS DISEASES
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引用次数: 0

Abstract

Objectives

With remarkable progress in the field of respiratory syncytial virus (RSV) prophylaxis, it is critical to understand population immunity against RSV. We aim to describe the RSV pre-F IgG antibodies across all age groups in Southern China and to evaluate the risk factors associated with lower antibody levels.

Methods

We performed a community-based cross-sectional sero-epidemiological study in Anhua County, Hunan Province, Southern China, from July 15, 2021, to November 5, 2021. Serum samples were tested for IgG antibodies against the RSV prefusion F (pre-F) protein using an enzyme-linked immunosorbent assay. We estimated the geometric mean titres (GMTs) and seropositivity rates across all age groups. The generalized linear models were built to identify factors associated with antibody levels.

Results

A total of 890 participants aged 4 months to older than 89 years were enrolled. The lowest RSV pre-F IgG GMTs were observed in infants and toddlers aged 4 months to younger than 2 years (3.0; 95% CI, 2.6–3.5). With increasing age, the RSV pre-F IgG GMT increased to 4.3 (95% CI, 4.1–4.4) between the ages of 2 and younger than 5 years and then stabilized at high levels throughout life. All the children had serological evidence of RSV infection by the age of 5 years. Age was associated with RSV pre-F antibody levels in children, with an estimated 1.9-fold (95% CI, 0.8–3.6) increase in titre per year before 5 years of age, although it was not significantly associated with antibody levels in adults aged older than 60 years.

Discussion

Our findings could provide a comprehensive understanding of the gaps in RSV immunity at the population level and inform the prioritization of immunization platforms.

呼吸道合胞病毒抗体反应:华南地区基于人群的横断面血清学研究,2021 年。
目标:随着RSV预防领域取得重大进展,了解人群对RSV的免疫力至关重要。我们旨在描述中国南方各年龄组人群的 RSV 前 F 免疫球蛋白 G (IgG) 抗体,并评估与抗体水平较低相关的风险因素:方法:2021 年 7 月至 11 月,我们在中国南方湖南省安化县开展了一项基于社区的横断面血清流行病学研究。采用酶联免疫吸附试验检测血清样本中针对 RSV 预融合 F(pre-F)蛋白的 IgG 抗体。我们估算了各年龄组的几何平均滴度(GMT)和血清阳性率。我们建立了广义线性模型(GLM),以确定与抗体水平相关的因素:共有 890 名年龄从 4 个月到 89 岁以上的参与者参加了研究。4个月至60岁的婴幼儿的RSV前F IgG GMT最低:我们的研究结果可以让人们全面了解人群中 RSV 免疫力的差距,并为确定免疫平台的优先次序提供依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
25.30
自引率
2.10%
发文量
441
审稿时长
2-4 weeks
期刊介绍: Clinical Microbiology and Infection (CMI) is a monthly journal published by the European Society of Clinical Microbiology and Infectious Diseases. It focuses on peer-reviewed papers covering basic and applied research in microbiology, infectious diseases, virology, parasitology, immunology, and epidemiology as they relate to therapy and diagnostics.
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