TNIK in disease: from molecular insights to therapeutic prospects

IF 6.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Apoptosis Pub Date : 2024-06-09 DOI:10.1007/s10495-024-01987-w

Xue Wu, Zhe Zhang, Zhenye Qiu, Xiaopeng Wu, Junmin Chen, Lu Liu, Xiaoyi Liu, Shiyan Zhao, Yang Yang, Ye Zhao

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Abstract

TRAF2 and NCK interacting kinase (TNIK), a critical interacting protein kinase, is currently receiving wide attention. TNIK is found in various human body organs and tissues and participates in cell motility, proliferation, and differentiation. On the one hand, its aberrant expression is related to the onset and progression of numerous malignant tumors. On the other hand, TNIK is important in neuronal growth, proliferation, differentiation, and synaptic formation. Thus, the novel therapeutic strategies for targeting TNIK offer a promising direction for cancer, neurological or psychotic disorders. Here, we briefly summarized the biological information of TNIK, reviewed the role and regulatory mechanism in cancer and neuropsychiatric diseases, and introduced the research progress of inhibitors targeting TNIK. Taken together, this review hopes to contribute to the in-depth understanding of the function and regulatory mechanism of TNIK, which is of great significance for revealing the role of TNIK in the occurrence and treatment of diseases.

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疾病中的 TNIK：从分子认识到治疗前景。

TRAF2 和 NCK 交互激酶（TNIK）是一种重要的交互蛋白激酶，目前正受到广泛关注。TNIK 存在于人体的各种器官和组织中，参与细胞的运动、增殖和分化。一方面，它的异常表达与许多恶性肿瘤的发生和发展有关。另一方面，TNIK 在神经元的生长、增殖、分化和突触形成中起着重要作用。因此，针对 TNIK 的新型治疗策略为癌症、神经或精神疾病的治疗提供了一个很有前景的方向。在此，我们简要总结了 TNIK 的生物学信息，回顾了其在癌症和神经精神疾病中的作用和调控机制，并介绍了靶向 TNIK 的抑制剂的研究进展。综上所述，本综述希望有助于深入了解TNIK的功能和调控机制，这对于揭示TNIK在疾病发生和治疗中的作用具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Apoptosis 生物-生化与分子生物学

CiteScore

9.10

自引率

4.20%

发文量

审稿时长

1 months

期刊介绍： Apoptosis, a monthly international peer-reviewed journal, focuses on the rapid publication of innovative investigations into programmed cell death. The journal aims to stimulate research on the mechanisms and role of apoptosis in various human diseases, such as cancer, autoimmune disease, viral infection, AIDS, cardiovascular disease, neurodegenerative disorders, osteoporosis, and aging. The Editor-In-Chief acknowledges the importance of advancing clinical therapies for apoptosis-related diseases. Apoptosis considers Original Articles, Reviews, Short Communications, Letters to the Editor, and Book Reviews for publication.