Thyroid autoimmunity in different phenotypes of polycystic ovary syndrome: a single-center experience.

IF 5.4 2区 医学 Q1 Medicine
E Benelli, M Marradi, E Sciarroni, C Di Cosmo, B Bagattini, S Del Ghianda, T Simoncini, F Fruzzetti, M Tonacchera, E Fiore
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引用次数: 0

Abstract

Purpose: Polycystic ovary syndrome (PCOS) has been associated with Hashimoto's thyroiditis (HT) and 4 phenotypes have been described in this syndrome. The aim of this work was to investigate the frequency of anti-thyroid antibodies (TAb) and thyroid function in the 4 phenotypes of PCOS.

Patients: This study included 448 patients with PCOS: 260 (58.0%) with phenotype A, 119 (26.6%) with phenotype B, 38 (8.5%) with phenotype C and 31 (6.9%) with phenotype D.

Results: TAb positivity was detected in 90/448 patients (20.1%) and was statistically significant higher (p = 0.03) in the grouped phenotypes A-B (83/379, 21.9%) than in phenotypes C-D (7/69, 10.1%). Positive anti-thyroglobulin antibodies (TgAb) were detected in 74/448 (16.5%) patients and positive anti-thyroperoxidase antibodies (TPOAb) in 66/448 (14.7%) patients. Both TgAb and TPOAb positivity was higher but not statistically significant in phenotype A-B than phenotype C-D. High titer TgAb (> 100 UI/ml) frequency was significantly higher (p = 0.005) in grouped phenotypes A-B (39/379, 10.3%) than in phenotypes C-D (0/69, 0.0%), while no significant difference was observed for low titer TgAb (≤ 100 UI/ml). According to a binary logistic regression analysis hypothyroidism was significantly associated with TAb positivity (OR 4.19; CI 2.25-7.79; p < 0.01) but not with PCOS phenotype. Androgen profile was not associated with TAb positivity.

Conclusion: A higher frequency of positive TAb and of high titer TgAb and TPOAb have been detected in PCOS women with phenotypes A and B, probably in relation to the greater imbalances between estrogen and progesterone levels present in these phenotypes.

Abstract Image

多囊卵巢综合征不同表型的甲状腺自身免疫:单中心经验。
目的:多囊卵巢综合征(PCOS)与桥本氏甲状腺炎(HT)有关,该综合征有4种表型。本研究旨在调查抗甲状腺抗体(TAb)的频率和多囊卵巢综合征 4 种表型的甲状腺功能:本研究共纳入 448 例多囊卵巢综合征患者:260 例(58.0%)为表型 A,119 例(26.6%)为表型 B,38 例(8.5%)为表型 C,31 例(6.9%)为表型 D:90/448名患者(20.1%)检测到TAb阳性,其中A-B组表型(83/379,21.9%)的TAb阳性率显著高于C-D组表型(7/69,10.1%)(P=0.03)。74/448(16.5%)名患者的抗甲状腺球蛋白抗体(TgAb)呈阳性,66/448(14.7%)名患者的抗甲状腺过氧化物酶抗体(TPOAb)呈阳性。表型 A-B 的 TgAb 和 TPOAb 阳性率均高于表型 C-D,但无统计学意义。高滴度 TgAb(> 100 UI/ml)频率在分组表型 A-B 中(39/379,10.3%)明显高于表型 C-D(0/69,0.0%)(p = 0.005),而低滴度 TgAb(≤ 100 UI/ml)则无明显差异。根据二元逻辑回归分析,甲状腺功能减退症与 TAb 阳性显著相关(OR 4.19;CI 2.25-7.79;P 结论:甲状腺功能减退症与 TAb 阳性显著相关:在表型为 A 和 B 的多囊卵巢综合症女性中,TAb 阳性以及高滴度 TgAb 和 TPOAb 的频率较高,这可能与这些表型中雌激素和孕激素水平失衡较严重有关。
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来源期刊
Journal of Endocrinological Investigation
Journal of Endocrinological Investigation ENDOCRINOLOGY & METABOLISM-
CiteScore
8.10
自引率
7.40%
发文量
242
期刊介绍: The Journal of Endocrinological Investigation is a well-established, e-only endocrine journal founded 36 years ago in 1978. It is the official journal of the Italian Society of Endocrinology (SIE), established in 1964. Other Italian societies in the endocrinology and metabolism field are affiliated to the journal: Italian Society of Andrology and Sexual Medicine, Italian Society of Obesity, Italian Society of Pediatric Endocrinology and Diabetology, Clinical Endocrinologists’ Association, Thyroid Association, Endocrine Surgical Units Association, Italian Society of Pharmacology.
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