Efficacy of submental island flap closing advanced mandibular MRONJ lesion in malignancy patients

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-06-08 DOI:10.1002/hed.27837

Hongyuan Huang BS, Qiao Qiao PhD, Ning Zhao PhD, Ying Zhou BS, Yiwen Zou BS, Qingxiang Li PhD, Siyuan Li MASc, Biao Zhou MASc, Yi Zhang MD, Chuanbin Guo MD, Yuxing Guo MD

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引用次数: 0

Abstract

Objective

This study evaluated the effectiveness of a submental island flap in closing advanced mandibular medication-related osteonecrosis of the jaw (MRONJ) wounds in patients with malignant tumors.

Subjects and methods

A total of 85 patients with stage II and III MRONJ of mandible with malignant tumor as their primary disease were retrospectively analyzed. All patients underwent surgical treatment, and the soft tissue wound closure was performed either with a submental island flap (SIF) or mucoperiosteal flap (MF). Univariate and multifactorial models were applied to analyze the factors influencing patients' prognosis.

Results

Univariate analysis (p = 0.004, OR 0.075–0.575, 95% CI) and binary logistic regression (p = 0.017, OR 0.032–0.713, 95% CI) suggested that the surgical prognosis of SIF wound closure was significantly better than that of MF.

Conclusion

Closure of wound after resection of mandibular MRONJ lesions in patients with malignant tumors using SIF had a better clinical prognosis compared with MF.

查看原文本刊更多论文

下颌岛状皮瓣关闭恶性肿瘤患者晚期下颌骨 MRONJ 病变的疗效。

目的本研究评估了下颌骨岛状皮瓣对恶性肿瘤患者晚期下颌骨药物性骨坏死（MRONJ）伤口闭合的有效性：回顾性分析以恶性肿瘤为原发疾病的下颌骨 MRONJ II 期和 III 期患者共 85 例。所有患者均接受了手术治疗，软组织伤口闭合采用了下颌骨岛状皮瓣（SIF）或粘骨膜瓣（MF）。应用单变量和多因素模型分析影响患者预后的因素：单变量分析（P = 0.004，OR 0.075-0.575，95% CI）和二元逻辑回归（P = 0.017，OR 0.032-0.713，95% CI）表明，SIF伤口闭合的手术预后明显优于MF：结论：与 MF 相比，恶性肿瘤患者下颌骨 MRONJ 病变切除术后使用 SIF 闭合伤口的临床预后更好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.