Maturation of the vertebral ring apophysis is delayed in girls with adolescent idiopathic scoliosis compared to the normal population.

IF 1.6 Q3 CLINICAL NEUROLOGY

Spine deformity Pub Date : 2024-11-01 Epub Date: 2024-06-07 DOI:10.1007/s43390-024-00908-w

Lorenzo Costa, Agnes van Lange, Peter R Seevinck, Winnie Chu, Ludvig Vavruch, Moyo C Kruyt, René M Castelein, Tom P C Schlosser

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引用次数: 0

Abstract

Purpose: The ring apophysis is a secondary ossification center on both sides of each vertebral body, to which the annulus of the intervertebral disc inserts. Recently, its pattern of ossification and fusion to the vertebral body was described for the normal growing spine. The aim of the present study was to investigate the ossification and fusion of the ring apophysis in patients with adolescent idiopathic scoliosis (AIS) and compare it to the normal growing population.

Methods: Ring apophysis maturation along the entire thoracic and lumbar spine was analyzed on CT scans of 99 female, pre-operative AIS patients and compared to 134 CT scans of non-scoliotic girls, aged 12 to 20.

Results: The ring apophysis maturation in AIS patients was delayed at all spinal levels in AIS patients compared to non-scoliotic controls. Ossification starts at T4-T11 at age 12, followed by T1-T5 and L3-S1 at age 15. The fusion process in AIS patients continues longer in the midthoracic region as compared to the other regions and as compared to non-scoliotic controls, with many incomplete fusions still at age 20.

Conclusion: The ring apophysis maturation in AIS is delayed compared to that in the normal population and lasts longer in the mid/low thoracic spine. Delayed maturation of the spine's most important stabilizer, while the body's dimensions continue to increase, could be part of the patho-mechanism of AIS.

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与正常人相比，患有青少年特发性脊柱侧弯症的女孩的椎骨环骨干成熟延迟。

目的：环状干骺端是每个椎体两侧的次要骨化中心，椎间盘的环状突插入其中。最近，有人描述了正常生长脊柱的骨化和与椎体融合的模式。本研究旨在调查青少年特发性脊柱侧弯症（AIS）患者环状骨干的骨化和融合情况，并将其与正常生长人群进行比较：方法：对99名术前特发性脊柱侧弯症（AIS）女性患者的CT扫描结果进行分析，并与134名12至20岁非脊柱侧弯症女孩的CT扫描结果进行比较，结果显示：整个胸椎和腰椎的环状干骺端均已成熟：结果：与非脊柱侧弯对照组相比，AIS 患者所有脊柱级别的环状骨干成熟都有所延迟。12 岁时，T4-T11 开始骨化，15 岁时，T1-T5 和 L3-S1 开始骨化。与其他区域和非脊柱侧弯对照组相比，AIS 患者中胸区域的融合过程持续时间更长，到 20 岁时仍有许多不完全融合：结论：与正常人相比，AIS 患者的环形骨干成熟延迟，中/低位胸椎的环形骨干成熟持续时间更长。脊柱最重要的稳定器延迟成熟，而身体的尺寸却在不断增加，这可能是 AIS 的病理机制之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Spine deformity

CiteScore

3.20

自引率

18.80%

发文量

167

期刊介绍： Spine Deformity the official journal of the?Scoliosis Research Society is a peer-refereed publication to disseminate knowledge on basic science and clinical research into the?etiology?biomechanics?treatment?methods and outcomes of all types of?spinal deformities. The international members of the Editorial Board provide a worldwide perspective for the journal's area of interest.The?journal?will enhance the mission of the Society which is to foster the optimal care of all patients with?spine?deformities worldwide. Articles published in?Spine Deformity?are Medline indexed in PubMed.? The journal publishes original articles in the form of clinical and basic research. Spine Deformity will only publish studies that have institutional review board (IRB) or similar ethics committee approval for human and animal studies and have strictly observed these guidelines. The minimum follow-up period for follow-up clinical studies is 24 months.