Comparison of MRI features among squamous cell carcinoma, adenocarcinoma and adenosquamous carcinoma, usual-type endocervical adenocarcinoma and gastric adenocarcinoma of cervix

IF 2.1 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic resonance imaging Pub Date : 2024-06-06 DOI:10.1016/j.mri.2024.06.002

Mei Ling Xiao , Le Fu , Feng Hua Ma , Yong Ai Li , Guo Fu Zhang , Jin Wei Qiang

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引用次数: 0

Abstract

Objective

To compare and explore the characteristics of squamous cell carcinoma (SCC), adenocarcinoma (AC) and adenosquamous carcinoma (ASC), usual-type endocervical adenocarcinoma (UEA) and gastric adenocarcinoma (GAC) of cervix.

Materials and methods

A total of 728 cervical cancers (254 cases of AC, 252 cases of ASC, and 222 cases of SCC) confirmed by histopathology were retrospectively reviewed. Among AC, 119 UEA and 47 GAC were included. Clinical baseline data and tumor morphological features on MRI (including tumor location, shape, diameter and volume, margin, growth pattern, presence of fluid component or cyst, heterogenous and peritumoral enhancement) of all cases were collected and analyzed. The signal intensity (SI) of tumor and gluteus maximus muscle were measured and their ratios (SIR) were calculated based on T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), apparent diffusion coefficient (ADC) and contrast-enhanced T1WI at arterial and delay phases (A/DCE-T1WI). These clinical and MRI features were compared between SCC, AC and ASC, UEA and GAC, and the specific ones of each subtype were identified.

Results

There was a significant difference in SCC-Ag, CA-199, CEA, ADC value, SIR-DWI, presence of intratumor cyst and peritumoral enhancement between AC and ASC; in patient age, menopausal status, International Federation of Gynecology and Obstetrics (FIGO) stage, SCC-Ag, CA-125, CA-199, CEA, tumor shape, growth pattern, margin, presence of intratumor fluid component and cyst, tumor diameter and volume, ADC value, SIR-T1WI, SIR-T2WI, and SIR-DWI between SCC and AC, as well as SCC and ASC. Also, there was a significant difference in deep stromal invasion (DSI), peritumoral and heterogenous enhancement between SCC and AC, and in SIR-ACE-T1WI between SCC and ASC. There was a significant difference in reproductive history, menopausal status, FIGO stage, CA-199, DSI, lymph node metastasis (LNM), parametrial invasion (PMI), tumor location, shape, margin, growth pattern, presence of fluid component and cyst, tumor diameter and volume, SIR-T1WI, SIR-DWI, and heterogenous enhancement between GAC and UEA.

Conclusion

The clinical and MRI features with significant differences among SCC, AC and ASC, and between UEA and GAC, can help to identify each subtype of cervical cancer.

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宫颈鳞状细胞癌、腺癌和腺鳞癌、普通型宫颈内膜腺癌和胃腺癌的磁共振特征比较。

目的比较并探讨宫颈鳞状细胞癌（SCC）、腺癌（AC）、腺鳞癌（ASC）、普通型宫颈内膜腺癌（UEA）和胃腺癌（GAC）的特征：回顾性分析经组织病理学证实的 728 例宫颈癌（254 例 AC、252 例 ASC 和 222 例 SCC）。在AC中，包括119例UEA和47例GAC。研究人员收集并分析了所有病例的临床基线数据和核磁共振成像上的肿瘤形态特征（包括肿瘤位置、形状、直径和体积、边缘、生长模式、有无液体成分或囊肿、异质和瘤周强化）。根据 T1 加权成像（T1WI）、T2 加权成像（T2WI）、弥散加权成像（DWI）、表观弥散系数（ADC）以及动脉期和延迟期对比增强 T1WI（A/DCE-T1WI），测量了肿瘤和臀大肌的信号强度（SI），并计算了两者的比值（SIR）。比较了 SCC、AC 和 ASC、UEA 和 GAC 的临床和 MRI 特征，并确定了各亚型的特殊特征：结果：SCC-Ag、CA-199、CEA、ADC 值、SIR-DWI、瘤内囊肿和瘤周强化在 AC 和 ASC 之间存在明显差异；在患者年龄、绝经状态、国际妇产科联盟（FIGO）分期、SCC-Ag、CA-125、CA-199、CEA、肿瘤形状、生长方式、边缘、瘤内液体成分和囊肿的存在、肿瘤直径和体积、ADC值、SIR-T1WI、SIR-T2WI和SIR-DWI方面，SCC与AC以及SCC与ASC存在显著差异。此外，SCC 和 AC 之间在基质深层浸润（DSI）、瘤周和异质增强方面存在显著差异，SCC 和 ASC 之间在 SIR-ACE-T1WI 方面也存在显著差异。GAC和UEA在生育史、绝经状态、FIGO分期、CA-199、DSI、淋巴结转移（LNM）、宫旁侵犯（PMI）、肿瘤位置、形状、边缘、生长方式、有无液体成分和囊肿、肿瘤直径和体积、SIR-T1WI、SIR-DWI和异质强化等方面均有显著差异：结论：SCC、AC 和 ASC 之间以及 UEA 和 GAC 之间差异显著的临床和 MRI 特征有助于鉴别宫颈癌的各个亚型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Magnetic resonance imaging 医学-核医学

CiteScore

4.70

自引率

4.00%

发文量

194

审稿时长

83 days

期刊介绍： Magnetic Resonance Imaging (MRI) is the first international multidisciplinary journal encompassing physical, life, and clinical science investigations as they relate to the development and use of magnetic resonance imaging. MRI is dedicated to both basic research, technological innovation and applications, providing a single forum for communication among radiologists, physicists, chemists, biochemists, biologists, engineers, internists, pathologists, physiologists, computer scientists, and mathematicians.