The emerging role of the semaphorin family in cartilage and osteoarthritis.

IF 2.1 4区 生物学 Q4 CELL BIOLOGY
Histochemistry and Cell Biology Pub Date : 2024-09-01 Epub Date: 2024-06-07 DOI:10.1007/s00418-024-02303-y
Wenjing Peng, Qian Chen, Fengjuan Zheng, Li Xu, Xinyi Fang, Zuping Wu
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引用次数: 0

Abstract

In the pathogenesis of osteoarthritis, various signaling pathways may influence the bone joint through a common terminal pathway, thereby contributing to the pathological remodeling of the joint. Semaphorins (SEMAs) are cell-surface proteins actively involved in and primarily responsible for regulating chondrocyte function in the pathophysiological process of osteoarthritis (OA). The significance of the SEMA family in OA is increasingly acknowledged as pivotal. This review aims to summarize the mechanisms through which different members of the SEMA family impact various structures within joints. The findings indicate that SEMA3A and SEMA4D are particularly relevant to OA, as they participate in cartilage injury, subchondral bone remodeling, or synovitis. Additionally, other elements such as SEMA4A and SEMA5A may also contribute to the onset and progression of OA by affecting different components of the bone and joint. The mentioned mechanisms demonstrate the indispensable role of SEMA family members in OA, although the detailed mechanisms still require further exploration.

Abstract Image

semaphorin家族在软骨和骨关节炎中的新作用。
在骨关节炎的发病机制中,各种信号通路可能通过共同的终端通路影响骨关节,从而导致关节的病理重塑。半aphorins(SEMA)是一种细胞表面蛋白,在骨关节炎(OA)的病理生理过程中积极参与并主要负责调节软骨细胞的功能。SEMA家族在OA中的重要性日益得到认可。本综述旨在总结SEMA家族不同成员影响关节内各种结构的机制。研究结果表明,SEMA3A 和 SEMA4D 与 OA 尤为相关,因为它们参与软骨损伤、软骨下骨重塑或滑膜炎。此外,SEMA4A 和 SEMA5A 等其他元素也可能通过影响骨和关节的不同组成部分而导致 OA 的发生和发展。上述机制表明,SEMA家族成员在OA中发挥着不可或缺的作用,但具体机制仍需进一步探索。
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来源期刊
Histochemistry and Cell Biology
Histochemistry and Cell Biology 生物-细胞生物学
CiteScore
4.90
自引率
8.70%
发文量
112
审稿时长
1 months
期刊介绍: Histochemistry and Cell Biology is devoted to the field of molecular histology and cell biology, publishing original articles dealing with the localization and identification of molecular components, metabolic activities and cell biological aspects of cells and tissues. Coverage extends to the development, application, and/or evaluation of methods and probes that can be used in the entire area of histochemistry and cell biology.
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