Abietane diterpenoids from Isodon amethystoides and their biological activities

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2024-06-04 DOI:10.1016/j.phytochem.2024.114171

Lang Zhou , Chen-Liang Zhao , Chuan-Yan Xu , Ming-Hong Dong , Jiang-Hai Ye , Jing-Jie Zhang , Lu-Tai Pan , Juan Zou , Hong-Jie Zhang

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Abstract

Seven undescribed abietane diterpenoids [abietamethinols A-G (1–7)] were isolated from the twigs and leaves of Isodon amethystoides. Their structures were elucidated on the basis of spectroscopic methods including 2D NMR, and they were further confirmed by X-ray crystallographic data. Lophanic acid was considered as the precursor of 1–7 in the biosynthesis pathway hypothesis. These compounds were evaluated for their cytotoxic, anti-bacterial and anti-AIV (avian influenza virus) activities. Compound 5 showed 42.9% inhibitory activity against the cancer cell line SMMC-7721 at the concentration of 40 μM, 3 and 4 could inhibit the bacterial growth of Streptococcus sobrinus by 55.3% and 63.2% at the concentrations of 148.6 and 141.9 μM, respectively, and 4 was demonstrated with antiviral activity against AIV with the inhibitory effect of 68.4% at 25 μM.

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Isodon amethystoides 中的 Abietane diterpenoids 及其生物活性。

从石莲花（Isodon amethystoides）的树枝和叶子中分离出了七种未曾描述过的罡烷二萜类化合物[罡烷甲酚 A-G (1-7)]。根据光谱方法（包括二维核磁共振）阐明了它们的结构，并通过 X 射线晶体学数据进一步证实了它们的结构。在生物合成途径假设中，洛巴尼酸被认为是 1-7 的前体。对这些化合物的细胞毒性、抗菌和抗 AIV（禽流感病毒）活性进行了评估。化合物 5 在 40 μM 的浓度下对癌细胞株 SMMC-7721 有 42.9% 的抑制活性；3 和 4 在 148.6 和 141.9 μM 的浓度下分别能抑制苏木链球菌 55.3% 和 63.2% 的细菌生长；4 在 25 μM 的浓度下对禽流感病毒有 68.4% 的抑制作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.