Perioperative Blood Transfusions and Cancer Progression: A Narrative Review.

IF 4.7 2区医学 Q1 ONCOLOGY

Current Oncology Reports Pub Date : 2024-08-01 Epub Date: 2024-06-07 DOI:10.1007/s11912-024-01552-3

Layal Abou Daher, Olivia Heppell, Ileana Lopez-Plaza, Carlos E Guerra-Londono

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Abstract

Purpose of review: To examine the most recent evidence about known controversies on the effect of perioperative transfusion on cancer progression.

Recent findings: Laboratory evidence suggests that transfusion-related immunomodulation can be modified by blood management and storage practices, but it is likely of less intensity than the effect of the surgical stress response. Clinical evidence has questioned the independent effect of blood transfusion on cancer progression for some cancers but supported it for others. Despite major changes in surgery and anesthesia, cancer surgery remains a major player in perioperative blood product utilization. Prospective data is still required to strengthen or refute existing associations. Transfusion-related immunomodulation in cancer surgery is well-documented, but the extent to which it affects cancer progression is unclear. Associations between transfusion and cancer progression are disease-specific. Increasing evidence shows autologous blood transfusion may be safe in cancer surgery.

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围手术期输血与癌症进展：叙述性综述。

综述目的：研究关于围手术期输血对癌症进展影响的已知争议的最新证据：实验室证据表明，输血相关的免疫调节可通过血液管理和储存方法改变，但其强度可能低于手术应激反应的影响。临床证据质疑输血对某些癌症进展的独立影响，但支持输血对其他癌症的影响。尽管手术和麻醉发生了重大变化，但癌症手术仍是围手术期血液制品使用的主要因素。仍需要前瞻性数据来加强或反驳现有的关联。癌症手术中与输血相关的免疫调节已得到充分证实，但其对癌症进展的影响程度尚不清楚。输血与癌症进展之间的关联是针对特定疾病的。越来越多的证据表明，自体输血在癌症手术中可能是安全的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Oncology Reports ONCOLOGY-

CiteScore

8.50

自引率

0.00%

发文量

187

审稿时长

6-12 weeks

期刊介绍： This journal aims to review the most important, recently published clinical findings in the field of oncology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by cancer. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as cancer prevention, leukemia, melanoma, neuro-oncology, and palliative medicine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.