Rational design, synthesis and biological evaluation of Isoxazole incorporated oxazol-4-yl-1-(pyridin-4-yl)-1H-pyrazole as anticancer agents

IF 2.218 Q2 Chemistry

Chemical Data Collections Pub Date : 2024-08-01 DOI:10.1016/j.cdc.2024.101146

引用次数: 0

Abstract

We have developed a new library of isoxazole skeleton having oxazol-4-yl)-1-(pyridin-4-yl)-1H-pyrazole derivatives (9a-j). Further, the biological activity of newly derived compounds (9a-j) was examined against four types of human cancer cell lines like breast cancer (MCF-7), lung cancer (A549), prostate cancer (DU-145) and breast cancer (MDA-MB-231) by employing of MTT assay, and etoposide used as reference drug candidate. The results were expressed with IC₅₀ µM. Most of the tested compounds displayed good to moderate activities on all cell lines. Among them, five derivatives 9a, 9b, 9c, 9d and 9e were possessed more potent activity. Principally, one of the compound 9b showed remarkable activity.

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作为抗癌剂的异噁唑并噁唑-4-基-1-(吡啶-4-基)-1H-吡唑的合理设计、合成和生物学评价

我们开发了一个新的异噁唑骨架库，其中含有噁唑-4-基）-1-(吡啶-4-基)-1H-吡唑衍生物（9a-j）。此外，还采用 MTT 法检测了新化合物（9a-j）对四种人类癌细胞系（如乳腺癌（MCF-7）、肺癌（A549）、前列腺癌（DU-145）和乳腺癌（MDA-MB-231））的生物活性，并以依托泊苷作为候选药物参考。结果以 IC50 µM 表示。大多数受试化合物对所有细胞系都显示出良好至中等程度的活性。其中，5 种衍生物 9a、9b、9c、9d 和 9e 具有更强的活性。其中，化合物 9b 显示出了显著的活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Data Collections Chemistry-Chemistry (all)

CiteScore

6.10

自引率

0.00%

发文量

169

审稿时长

24 days

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