{"title":"Classic Hodgkin lymphoma transformation into composite lymphoma complicated with Guillain‒Barré syndrome after chemotherapy: A case report","authors":"Li He, Ying Bao","doi":"10.1016/j.cpccr.2024.100303","DOIUrl":null,"url":null,"abstract":"<div><p>Classic Hodgkin lymphoma rarely undergoes pathological transformation, and the transformation type is usually common non-Hodgkin lymphoma. This study describes a 71-year-old male diagnosed with stage III classic Hodgkin lymphoma positive for Epstein‒Barr virus. The disease was partially relieved soon after chemotherapy but quickly progressed with transformation into composite lymphoma with a mixture of T and B cells. Then he developed symptoms in his nervous system and was diagnosed with Guillain‒Barré syndrome. EBV remained positive throughout the course of the disease. Classic Hodgkin lymphoma may transform into composite lymphoma, and the composite lymphoma may be complicated with Guillain‒Barré syndrome after chemotherapy. We hypothesized that EBV infection may play a role in the progression of the disease.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666621924000267/pdfft?md5=d52393ce34d5ad93c828f7bd8f6bc877&pid=1-s2.0-S2666621924000267-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current problems in cancer. Case reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666621924000267","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Classic Hodgkin lymphoma rarely undergoes pathological transformation, and the transformation type is usually common non-Hodgkin lymphoma. This study describes a 71-year-old male diagnosed with stage III classic Hodgkin lymphoma positive for Epstein‒Barr virus. The disease was partially relieved soon after chemotherapy but quickly progressed with transformation into composite lymphoma with a mixture of T and B cells. Then he developed symptoms in his nervous system and was diagnosed with Guillain‒Barré syndrome. EBV remained positive throughout the course of the disease. Classic Hodgkin lymphoma may transform into composite lymphoma, and the composite lymphoma may be complicated with Guillain‒Barré syndrome after chemotherapy. We hypothesized that EBV infection may play a role in the progression of the disease.
典型霍奇金淋巴瘤很少发生病理转化，转化类型通常是常见的非霍奇金淋巴瘤。本研究描述了一名 71 岁男性患者，诊断为典型霍奇金淋巴瘤 III 期，Epstein-Barr 病毒阳性。化疗后病情很快得到部分缓解，但很快又发展为 T 细胞和 B 细胞混合型复合淋巴瘤。随后，他的神经系统出现症状，被诊断为格林-巴利综合征。在整个病程中，EB病毒一直呈阳性。典型的霍奇金淋巴瘤可能转变为复合淋巴瘤，复合淋巴瘤在化疗后可能并发格林-巴利综合征。我们推测，EB病毒感染可能在疾病进展过程中起了作用。
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