The Promotive and Inhibitory Role of Long Non-Coding RNAs in Endometrial Cancer Course—A Review

Cancers Pub Date : 2024-06-03 DOI:10.3390/cancers16112125

P. Jasielski, Izabela Zawlik, Anna Bogaczyk, N. Potocka, Sylwia Paszek, Michał Maźniak, Aleksandra Witkoś, Adrianna Korzystka, Aleksandra Kmieć, Tomasz Kluz

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Abstract

Endometrial cancer is one of the most common malignant tumours in women. The development of this tumour is associated with several genetic disorders, many of which are still unknown. One type of RNA molecules currently being intensively studied in many types of cancer are long non-coding RNAs (lncRNAs). LncRNA-coding genes occupy a large fraction of the human genome. LncRNAs regulate many aspects of cell development, metabolism, and other physiological processes. Diverse types of lncRNA can function as a tumour suppressor or an oncogene that can alter migration, invasion, cell proliferation, apoptosis, and immune system response. Recent studies suggest that selected lncRNAs are important in an endometrial cancer course. Our article describes over 70 lncRNAs involved in the development of endometrial cancer, which were studied via in vivo and in vitro research. It was proved that lncRNAs could both promote and inhibit the development of endometrial cancer. In the future, lncRNAs may become an important therapeutic target. The aim of this study is to review the role of lncRNAs in the development of carcinoma of uterine body.

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长非编码 RNA 在子宫内膜癌病程中的促进和抑制作用--综述

子宫内膜癌是女性最常见的恶性肿瘤之一。子宫内膜癌的发生与多种遗传疾病有关，其中许多疾病尚不为人所知。长非编码 RNA（lncRNA）是目前在多种癌症中被深入研究的一种 RNA 分子。LncRNA 编码基因占人类基因组的很大一部分。LncRNA 调节细胞发育、新陈代谢和其他生理过程的许多方面。不同类型的 lncRNA 可作为肿瘤抑制因子或致癌基因发挥作用，从而改变迁移、侵袭、细胞增殖、细胞凋亡和免疫系统反应。最近的研究表明，某些 lncRNA 在子宫内膜癌的病程中具有重要作用。我们的文章介绍了通过体内和体外研究发现的与子宫内膜癌发展有关的 70 多个 lncRNA。研究证明，lncRNA 既能促进也能抑制子宫内膜癌的发展。未来，lncRNAs 可能成为重要的治疗靶点。本研究旨在综述lncRNAs在子宫体癌发展过程中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cancers

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