NELL-1 as a Target Antigen in Asbestosis Associated Membranous Nephropathy — A Case Report

Abstract

An 80-year-old male with a history of prolonged asbestos exposure presented with 24-hour urine protein of 8 gm, and serum albumin of 1.7 gm/dl. Renal biopsy disclosed features of membranous nephropathy. Immunohistochemistry showed positivity for neural epidermal-like growth factor- like 1 (NELL1) (2+/3+). Further assessment uncovered an incidental finding of asbestos-related pleural plaques and left hemithorax volume loss on computed tomography (CT) chest, leading to a diagnosis of asbestosis. This case highlights the rare association between asbestosis and NELL-1 positive membranous nephropathy.