Effects of resistance exercise and whey protein supplementation on cognitive function in older men: secondary analysis of a randomised, double-blind, placebo-controlled trial

IF 3.9

Experimental gerontology Pub Date : 2024-06-06 DOI:10.1016/j.exger.2024.112477

Corbin Griffen , Tom Cullen , John Hattersley , Martin O. Weickert , Alexander Dallaway , Michael Duncan , Derek Renshaw

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引用次数: 0

Abstract

Purpose

Ageing is associated with cognitive decline. This study investigated the individual and combined effects of resistance exercise (RE) and whey protein supplementation (PRO) on cognitive function in older men.

Methods

In a pooled-groups analysis, 36 older men (age: 67 ± 4 years) were randomised to either RE (2 x/week; n = 18) or no exercise (NE; n = 18), and either PRO (2 × 25 g/d whey protein isolate; n = 18) or control (CON, 2 × 23.75 g maltodextrin/d; n = 18). A sub-analysis was also conducted between RE + CON (n = 9) and RE + PRO (n = 9). At baseline and 12 weeks, participants completed a battery of neuropsychological tests (CANTAB; Cambridge Cognition, UK) and neurobiological, inflammatory, salivary cortisol and insulin sensitivity biomarkers were quantified.

Results

PRO improved executive function z-score (+0.31 ± 0.08) greater than CON (+0.06 ± 0.08, P = 0.03) and there was a trend towards improved global cognitive function (P = 0.053). RE and RE + PRO did not improve any cognitive function domains (p ≥ 0.07). RE decreased tumor necrosis factor-alpha (P = 0.02) and interleukin-6 (P = 0.048) concentrations compared to NE, but changes in biomarkers did not correlate with changes in cognitive domains. Muscle strength (r = 0.34, P = 0.045) and physical function (ρ = 0.35–0.51, P < 0.05) outcomes positively correlated with cognitive function domains at baseline, but only Δskeletal muscle index correlated with Δepisodic memory (r = 0.34, P = 0.046) following the intervention.

Conclusion

In older men, PRO improved cognitive function, most notably executive functioning. RE did not improve any cognitive function domains but did decrease biomarkers of systemic inflammation. No synergistic effects were observed.

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阻力运动和补充乳清蛋白对老年男性认知功能的影响：随机、双盲、安慰剂对照试验的二次分析

目的衰老与认知能力下降有关。本研究调查了抗阻力运动（RE）和乳清蛋白补充剂（PRO）对老年男性认知功能的单独和联合影响。方法在一项汇总组分析中，36 名老年男性（年龄：67 ± 4 岁）被随机分配进行抗阻力运动（2 次/周；n = 18）或不运动（NE；n = 18），以及乳清蛋白补充剂（2 × 25 克/天分离乳清蛋白；n = 18）或对照组（CON，2 × 23.75 克麦芽糊精/天；n = 18）。还对 RE + CON（9 人）和 RE + PRO（9 人）进行了子分析。在基线和 12 周时，参与者完成了一系列神经心理学测试（CANTAB；英国剑桥认知公司），并对神经生物学、炎症、唾液皮质醇和胰岛素敏感性生物标志物进行了量化。结果PRO 对执行功能 z 评分（+0.31 ± 0.08）的改善幅度大于 CON（+0.06 ± 0.08，P = 0.03），并且有改善整体认知功能的趋势（P = 0.053）。RE 和 RE + PRO 没有改善任何认知功能领域（P ≥ 0.07）。与 NE 相比，RE 降低了肿瘤坏死因子-α（P = 0.02）和白细胞介素-6（P = 0.048）的浓度，但生物标志物的变化与认知功能领域的变化无关。肌肉力量（r = 0.34，P = 0.045）和身体功能（ρ = 0.35-0.51，P < 0.05）结果与基线时的认知功能域呈正相关，但只有Δ骨骼肌指数与干预后的Δ表象记忆相关（r = 0.34，P = 0.046）。RE没有改善任何认知功能领域，但确实降低了全身炎症的生物标志物。没有观察到协同效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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