Potential Urine and Serum Biomarkers in Patients with Bladder Pain Syndrome/Interstitial Cystitis.

IF 0.6 4区医学 Q4 UROLOGY & NEPHROLOGY

Archivos Espanoles De Urologia Pub Date : 2024-05-01 DOI:10.56434/j.arch.esp.urol.20247704.48

Lei Wang, Jingyu Gao, Sufen Zheng, Zhao Wang, Shuo Zheng, Zijing Luo

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引用次数: 0

Abstract

Background: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a common chronic disease, and its aetiology and pathogenesis remain unclear. This study aimed to identify potential urine and serum biomarkers in patients with IC/BPS to further understand the pathogenesis and diagnosis of the disease.

Methods: Patients with IC/BPS diagnosed and treated in the First Hospital of Hebei Medical University from 1 July 2021 to 30 July 2023 were selected. The urine and serum biomarkers of 50 patients with IC/BPS were investigated and compared with the urine and serum samples of 50 healthy controls. IBM SPSS Statistics 26.0 was used for statistical analysis of the recorded data by using chi-square test, T-test and logistic regression analysis.

Results: Overall, 50 patients with IC/BPS (mean age, 54.20 ± 8.15 years) were included in the study. Those with history of urinary diseases, anxiety or depression were susceptible to IC/BPS. Levels of interleukin (IL)-6, tumor necrosis factor-α (TNF-α), nerve growth factor, and prostaglandin E2 (PGE2) in urine, as well as IL-8, TNF-α, and PGE2 in serum, were found to significantly increase in patients with interstitial cystitis/bladder pain syndrome (IC/BPS). These differences were statistically significant (p < 0.05). Multifactor analysis showed that anxiety, depression, IL-6, IL-8, TNF-α and PEG2 are risk factors for patients with IC/BPS.

Conclusions: Multiple biomarkers were identified in the urine and serum of patients with IC/BPS, suggesting a potential close relationship to the pathogenesis of IC/BPS.

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膀胱疼痛综合征/间质性膀胱炎患者的潜在尿液和血清生物标记物

背景：间质性膀胱炎/膀胱疼痛综合征（IC/BPS）是一种常见的慢性疾病，其病因和发病机制尚不清楚。本研究旨在确定IC/BPS患者潜在的尿液和血清生物标志物，以进一步了解该病的发病机制和诊断方法：方法：选取2021年7月1日至2023年7月30日在河北医科大学第一医院诊治的IC/BPS患者。研究50例IC/BPS患者的尿液和血清生物标志物，并与50例健康对照者的尿液和血清样本进行比较。采用 IBM SPSS Statistics 26.0 对记录的数据进行统计分析，方法包括卡方检验、T 检验和逻辑回归分析：研究共纳入 50 名 IC/BPS 患者（平均年龄为 54.20 ± 8.15 岁）。有泌尿系统疾病、焦虑或抑郁病史者易患 IC/BPS。研究发现，间质性膀胱炎/膀胱疼痛综合征（IC/BPS）患者尿液中的白细胞介素（IL）-6、肿瘤坏死因子-α（TNF-α）、神经生长因子和前列腺素 E2（PGE2）水平，以及血清中的 IL-8、TNF-α 和 PGE2 水平均显著升高。这些差异具有统计学意义（P < 0.05）。多因素分析表明，焦虑、抑郁、IL-6、IL-8、TNF-α 和 PEG2 是 IC/BPS 患者的风险因素：结论：在IC/BPS患者的尿液和血清中发现了多种生物标志物，表明它们与IC/BPS的发病机制可能存在密切关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archivos Espanoles De Urologia UROLOGY & NEPHROLOGY-

CiteScore

0.90

自引率

0.00%

发文量

111

期刊介绍： Archivos Españoles de Urología published since 1944, is an international peer review, susbscription Journal on Urology with original and review articles on different subjets in Urology: oncology, endourology, laparoscopic, andrology, lithiasis, pediatrics , urodynamics,... Case Report are also admitted.