Enhancing surgical precision in early-stage non-small cell lung cancer: A novel approach through temporary pulmonary vascular occlusion.

IF 2.3 3区 医学 Q3 ONCOLOGY
Thoracic Cancer Pub Date : 2024-07-01 Epub Date: 2024-06-04 DOI:10.1111/1759-7714.15388
Yan Zhao, Bin You, Hui Li
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引用次数: 0

Abstract

Background: To evaluate a novel intraoperative localization technique utilizing temporary pulmonary arteriovenous occlusion for enhancing the precision of sublobar resections in early-stage NSCLC.

Methods: Conducted from January to November 2023, this study involved 140 patients. During the surgery, key pulmonary vessels were identified using preoperative three-dimensional (3D) imaging and temporarily occluded with noninvasive clamps to isolate the target lung segment. Following vascular occlusion, indocyanine green (ICG) was administered intravenously to precisely delineate the resection margins. After visually confirming the marked areas, the clamps were released, and a targeted partial resection was performed on the delineated segment. Surgical data, including operation times, surgical margins, and hospitalization costs, were collected and compared with those from a historical control group of 110 patients who underwent traditional pulmonary wedge resections.

Results: In the study group, the median surgical margin achieved was 16 mm, which was statistically significant compared to 15 mm in the control group (p < 0.05). Operation times were reduced to an average of 58.43 ± 12.962 min, showing a decrease from the control group's average of 69.50 ± 17.544 min (p < 0.05). Hospitalization costs were also lower, averaging $4772.98 ± 624.339 for the study group versus $5161.34 ± 856.336 for the control group (p < 0.05). Patient safety was maintained with no increase in surgical complications.

Conclusion: The technique, leveraging temporary pulmonary arteriovenous occlusion, offered a significant advancement in the surgical treatment of peripheral early-stage NSCLC. It reduced operation time and lowered overall surgical costs. This method represented a promising alternative to traditional surgical approaches.

提高早期非小细胞肺癌手术的精确性:通过暂时性肺血管闭塞的新方法
背景:评估一种利用临时肺动静脉闭塞提高早期 NSCLC 亚叶状切除术精确性的新型术中定位技术:目的:评估一种利用临时肺动静脉闭塞提高早期NSCLC叶下切除术精确度的新型术中定位技术:本研究于2023年1月至11月进行,共有140名患者参与。在手术过程中,使用术前三维(3D)成像确定关键肺血管,并使用无创夹钳暂时闭塞,以隔离肺靶区。血管闭塞后,静脉注射吲哚菁绿(ICG)以精确划定切除边缘。在目测确认标记区域后,松开夹钳,在划定的肺段进行靶向部分切除。研究人员收集了手术数据,包括手术时间、手术切缘和住院费用,并将这些数据与历史对照组中 110 名接受传统肺楔形切除术的患者的数据进行了比较:研究组的中位手术切缘为 16 毫米,与对照组的 15 毫米相比,差异有统计学意义(P该技术利用暂时性肺动静脉闭塞,在外周早期 NSCLC 的手术治疗方面取得了重大进展。它缩短了手术时间,降低了手术总成本。这种方法有望取代传统的手术方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Thoracic Cancer
Thoracic Cancer ONCOLOGY-RESPIRATORY SYSTEM
CiteScore
5.20
自引率
3.40%
发文量
439
审稿时长
2 months
期刊介绍: Thoracic Cancer aims to facilitate international collaboration and exchange of comprehensive and cutting-edge information on basic, translational, and applied clinical research in lung cancer, esophageal cancer, mediastinal cancer, breast cancer and other thoracic malignancies. Prevention, treatment and research relevant to Asia-Pacific is a focus area, but submissions from all regions are welcomed. The editors encourage contributions relevant to prevention, general thoracic surgery, medical oncology, radiology, radiation medicine, pathology, basic cancer research, as well as epidemiological and translational studies in thoracic cancer. Thoracic Cancer is the official publication of the Chinese Society of Lung Cancer, International Chinese Society of Thoracic Surgery and is endorsed by the Korean Association for the Study of Lung Cancer and the Hong Kong Cancer Therapy Society. The Journal publishes a range of article types including: Editorials, Invited Reviews, Mini Reviews, Original Articles, Clinical Guidelines, Technological Notes, Imaging in thoracic cancer, Meeting Reports, Case Reports, Letters to the Editor, Commentaries, and Brief Reports.
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