Right-sided versus left-sided colorectal cancer in elderly patients: a sub-analysis of a large multicenter case-control study in Japan.

IF 1.7 4区医学 Q2 SURGERY

Surgery Today Pub Date : 2024-10-01 Epub Date: 2024-06-05 DOI:10.1007/s00595-024-02827-9

Haruki Sada, Takao Hinoi, Hiroaki Niitsu, Hideki Ohdan, Seiichiro Yamamoto, Shungo Endo, Koya Hida, Yusuke Kinugasa, Toshiyuki Enomoto, Satoshi Maruyama, Fumio Konishi, Masahiko Watanabe

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引用次数: 0

Abstract

Purpose: This study investigated the impact of sidedness of colorectal cancer (CRC) in elderly patients on the prognosis.

Methods: In a sub-analysis of a multicenter case-control study of CRC patients who underwent surgery at ≥ 80 years old conducted in Japan between 2003 and 2007, both short- and long-term outcomes were compared between right-sided colon cancers (RCCs) and left-sided colorectal cancers (LCCs). RCCs were defined as those located from the cecum to the transverse colon.

Results: Among the 1680 patients who underwent curative surgery, 812 and 868 had RCCs and LCCs, respectively. RCCs were more frequent than LCCs in those who were female, had renal comorbidities, and had a history of abdominal surgery. Regarding tumor characteristics, RCCs were larger, invaded more deeply, and were diagnosed as either mucinous or signet ring-cell carcinoma more frequently than LCCs. Regarding the prognosis, patients with RCCs had a significantly longer cancer-specific survival (CS-S) and cancer-specific relapse-free survival (CS-RFS) than those with LCCs. Furthermore, sidedness was determined to be an independent prognostic factor for CS-S and CS-RFS.

Conclusion: RCCs, which accounted for half of the cases in patients ≥ 80 years old, showed better long-term outcomes than LCCs.

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老年患者的右侧与左侧结直肠癌：日本一项大型多中心病例对照研究的子分析。

目的：本研究探讨了老年结直肠癌（CRC）患者偏侧对预后的影响：2003年至2007年间，日本对年龄≥80岁接受手术的CRC患者进行了一项多中心病例对照研究，在该研究的一项子分析中，比较了右侧结肠癌（RCC）和左侧结肠癌（LCC）的短期和长期预后。右侧结肠癌的定义是从盲肠到横结肠的结肠癌：在接受根治性手术的1680名患者中，分别有812人和868人患有RCC和LCC。在女性、有肾脏合并症和腹部手术史的患者中，RCC的发病率高于LCC。在肿瘤特征方面，RCC 比 LCC 更大，侵犯更深，更常被诊断为粘液腺癌或标志环细胞癌。在预后方面，RCC患者的癌症特异性生存期（CS-S）和癌症特异性无复发生存期（CS-RFS）明显长于LCC患者。此外，侧位被确定为CS-S和CS-RFS的独立预后因素：结论：RCC占≥80岁患者病例的一半，其长期预后优于LCC。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgery Today 医学-外科

CiteScore

4.90

自引率

4.00%

发文量

208

审稿时长

1 months

期刊介绍： Surgery Today is the official journal of the Japan Surgical Society. The main purpose of the journal is to provide a place for the publication of high-quality papers documenting recent advances and new developments in all fields of surgery, both clinical and experimental. The journal welcomes original papers, review articles, and short communications, as well as short technical reports("How to do it"). The "How to do it" section will includes short articles on methods or techniques recommended for practical surgery. Papers submitted to the journal are reviewed by an international editorial board. Field of interest: All fields of surgery.