Effective exosomes reduction in hypercholesterinemic patients suffering from cardiovascular diseases by lipoprotein apheresis: Exosomes apheresis.

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Pub Date : 2024-12-01 Epub Date: 2024-06-04 DOI:10.1111/1744-9987.14172

Sophie Schröder, Robert Epple, Andre Fischer, Volker J J Schettler

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Abstract

Introduction: Extracellular vesicles (EVs) have been identified as playing a role in atherosclerosis.

Methods: A group of 37 hypercholesterolemic patients with atherosclerotic cardiovascular diseases (ASCVD) and 9 patients requiring hemodialysis (HD) were selected for the study.

Results: EVs were comparably reduced by various LA methods (Thermo: 87.66% ± 3.64, DALI: 87.96% ± 4.81, H.E.L.P.: 83.38% ± 11.98; represented as SEM). However, LDL-C (66%; 55%; 75%) and Lp(a) (72%; 67%; 79%) were less effectively reduced by DALI. There was no significant difference in the reduction of EVs when comparing different techniques, such as hemoperfusion (DALI; n = 13), a precipitation (H.E.L.P.; n = 5), and a double filtration procedure (Thermofiltration; n = 19). Additionally, no effect of hemodialysis on EVs reduction was found.

Conclusions: The study suggests that EVs can be effectively removed by various LA procedures, and this effect appears to be independent of the specific LA procedure used, as compared to hemodialysis.

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通过脂蛋白清除术有效减少心血管疾病高胆固醇血症患者体内的外泌体：外泌体分离。

引言细胞外囊泡（EVs）已被确认在动脉粥样硬化中发挥作用：研究选择了37名患有动脉粥样硬化性心血管疾病（ASCVD）的高胆固醇血症患者和9名需要血液透析（HD）的患者：各种 LA 方法均可显著降低 EVs（Thermo：87.66% ± 3.64；DALI：87.96% ± 4.81；H.E.L.P. ：83.38% ± 11.98；以 SEM 表示）。然而，DALI降低低密度脂蛋白胆固醇（66%；55%；75%）和脂蛋白（a）（72%；67%；79%）的效果较差。比较不同的技术，如血液灌流（DALI；n = 13）、沉淀（H.E.L.P.；n = 5）和双重过滤程序（Thermofiltration；n = 19），在减少 EVs 方面没有明显差异。此外，血液透析对减少 EVs 没有影响：该研究表明，与血液透析相比，各种LA程序都能有效清除EVs，而且这种效果似乎与所使用的特定LA程序无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

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