Fe-S biogenesis by SMS and SUF pathways: A focus on the assembly step

IF 4.6 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Molecular cell research Pub Date : 2024-06-03 DOI:10.1016/j.bbamcr.2024.119772

Macha Dussouchaud , Frédéric Barras , Sandrine Ollagnier de Choudens

引用次数: 0

Abstract

FeS clusters are prosthetic groups present in all organisms. Proteins with FeS centers are involved in most cellular processes. ISC and SUF are machineries necessary for the formation and insertion of FeS in proteins. Recently, a phylogenetic analysis on more than 10,000 genomes of prokaryotes have uncovered two new systems, MIS and SMS, which were proposed to be ancestral to ISC and SUF. SMS is composed of SmsBC, two homologs of SufBC(D), the scaffolding complex of SUF. In this review, we will specifically focus on the current knowledge of the SUF system and on the new perspectives given by the recent discovery of its ancestor, the SMS system.

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SMS 和 SUF 途径的 Fe-S 生物生成：聚焦组装步骤。

FeS 簇是存在于所有生物体内的修复基团。带有 FeS 中心的蛋白质参与了大多数细胞过程。ISC和SUF是蛋白质中形成和插入FeS的必要机制。最近，对 10,000 多个原核生物基因组进行的系统发育分析发现了两个新系统，即 MIS 和 SMS，它们被认为是 ISC 和 SUF 的祖先。SMS 由 SmsBC 和 SUF 的支架复合物 SufBC(D) 的两个同源物组成。在这篇综述中，我们将特别关注目前对 SUF 系统的了解，以及最近发现其祖先 SMS 系统所带来的新视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochimica et biophysica acta. Molecular cell research 生物-生化与分子生物学

CiteScore

10.00

自引率

2.00%

发文量

151

审稿时长

44 days

期刊介绍： BBA Molecular Cell Research focuses on understanding the mechanisms of cellular processes at the molecular level. These include aspects of cellular signaling, signal transduction, cell cycle, apoptosis, intracellular trafficking, secretory and endocytic pathways, biogenesis of cell organelles, cytoskeletal structures, cellular interactions, cell/tissue differentiation and cellular enzymology. Also included are studies at the interface between Cell Biology and Biophysics which apply for example novel imaging methods for characterizing cellular processes.