Efficacy and safety of acupuncture therapy for neuropsychiatric symptoms among patients with Parkinson's disease: A systematic review and meta-analysis.

IF 2.6 3区医学 Q1 REHABILITATION

Clinical Rehabilitation Pub Date : 2024-08-01 Epub Date: 2024-06-05 DOI:10.1177/02692155241258278

Weiqiang Tan, Fengxi Xie, Jixi Zhou, Zhaoquan Pan, Muxi Liao, Lixing Zhuang

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引用次数: 0

Abstract

Objective: To systematically evaluate the efficacy and safety of acupuncture therapy for neuropsychiatric symptoms in patients with Parkinson's disease.

Methods: We searched eight databases from their inception until 14 April 2024, including PubMed, Cochrane Library, Embase, Web of Science, SinoMed, China National Knowledge Infrastructure, China Science and Technology Periodical Database, and Wanfang Database. The search aimed to find randomized controlled trials assessing the effectiveness of acupuncture for neuropsychiatric symptoms in patients with Parkinson's disease. Literature screening and data extraction were performed independently by the authors. Meta-analysis was conducted using RevMan V.5.3 software, and Stata 17.0 software was used for detecting publication bias and performing sensitivity analysis.

Results: Twenty-eight studies, involving 2148 participants, met the inclusion criteria. The meta-analysis revealed that acupuncture therapy improved depression-related scale scores (standardized mean difference (SMD) = -0.70, 95%CI [-0.98, -0.42], p < 0.00001), anxiety-related scale scores (SMD = -0.78, 95% CI [-1.43, -0.14], p = 0.02), Montreal Cognitive Assessment scores (weighted mean difference (WMD) = 2.74, 95% CI [2.43, 3.05], p < 0.00001), Mini Mental State Examination scores (WMD = 2.36, 95% CI [0.78, 3.94], p = 0.003), Yale-Brown Obsessive Compulsive Scale scores, and Parkinson's Disease Questionnaire-39 scores (WMD = -2.66, 95% CI [-4.83, -0.49], p = 0.02) compared to controls.

Conclusion: This review supports the application of acupuncture to reduce the severity of neuropsychiatric symptoms including depression, anxiety, and impulse control disorders, and to improve cognition and quality of life in patients with Parkinson's disease. The adverse effects associated with acupuncture, either alone or as adjunctive therapy, were relatively minor.

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针灸治疗帕金森病患者神经精神症状的有效性和安全性：系统回顾与荟萃分析。

目的：系统评估针灸疗法对帕金森病患者神经精神症状的疗效和安全性：系统评估针灸治疗帕金森病患者神经精神症状的有效性和安全性：我们检索了从开始到2024年4月14日的8个数据库，包括PubMed、Cochrane Library、Embase、Web of Science、SinoMed、中国国家知识基础设施、中国科技期刊数据库和万方数据库。该检索旨在寻找评估针灸对帕金森病患者神经精神症状疗效的随机对照试验。文献筛选和数据提取由作者独立完成。使用RevMan V.5.3软件进行Meta分析，并使用Stata 17.0软件检测发表偏倚和进行敏感性分析：符合纳入标准的研究有 28 项，涉及 2148 名参与者。荟萃分析显示，针灸疗法改善了抑郁相关量表评分（标准化平均差（SMD）= -0.70，95%CI [-0.98，-0.42]，P = 0.02）、蒙特利尔认知评估评分（加权平均差（WMD）= 2.74，95% CI [2.43，3.05]，p p = 0.003）、耶鲁-布朗强迫量表评分和帕金森病问卷-39评分（WMD = -2.66，95% CI [-4.83，-0.49]，p = 0.02）与对照组相比均有显著性差异：本综述支持应用针灸减轻帕金森病患者神经精神症状的严重程度，包括抑郁、焦虑和冲动控制障碍，并改善认知和生活质量。无论是单独使用针灸还是作为辅助疗法，与针灸相关的不良反应都相对较小。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Rehabilitation 医学-康复医学

CiteScore

5.60

自引率

6.70%

发文量

117

审稿时长

4-8 weeks

期刊介绍： Clinical Rehabilitation covering the whole field of disability and rehabilitation, this peer-reviewed journal publishes research and discussion articles and acts as a forum for the international dissemination and exchange of information amongst the large number of professionals involved in rehabilitation. This journal is a member of the Committee on Publication Ethics (COPE)