Intraovarian platelet-rich plasma injection in poor responders.

IF 1.8 Q3 OBSTETRICS & GYNECOLOGY

Jornal Brasileiro de Reproducao Assistida Pub Date : 2024-08-26 DOI:10.5935/1518-0557.20240031

Luciana María Devenutto, Gastón Rey Valzacchi, Marianela Ercolano, Orlando Etchegoyen

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引用次数: 0

Abstract

Objective: To evaluate if it possible to improve ovarian reserve parameters and oocyte retrieval in poor responders who undergo intraovarian injection of platelet-rich plasma (PRP).

Methods: Prospective cohort study. We included 148 poor responders who underwent PRP injection between October 2021 and December 2022 in our institution, comparing pre and post PRP ovarian function. In addition, the IVF outcomes of a subgroup of patients was studied after the intervention in contrast with the previous treatment.

Results: An improvement in ovarian reserve was observed in relation to previous values: FSH (13.57 vs. 11.32, p=0.11), AMH (0.39 vs. 0.48, p=0.06), antral follicle count (3.98 vs. 5.75, p<0.001); as well as a higher number of oocytes retrieved (2.63 vs. 3.65, p=0.01) and produced embryos (1.64 vs. 2.22, p=0.03); without a great impact on pregnancy rates.

Conclusions: Although experimental, intraovarian PRP could restore ovarian function and be postulated as an alternative to oocyte donation in patients with low ovarian reserve who do not accept this treatment. There is a lack of randomized controlled trials to support these findings.

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对反应不佳者进行卵巢内血小板丰富血浆注射。

目的评估对卵巢内注射富血小板血浆（PRP）反应不佳者是否有可能改善卵巢储备参数和卵母细胞检索：前瞻性队列研究。我们纳入了 2021 年 10 月至 2022 年 12 月期间在我院接受 PRP 注射的 148 例反应不佳者，比较了 PRP 前和 PRP 后的卵巢功能。此外，我们还研究了干预后与之前治疗相比，一部分患者的试管婴儿结果：结果：与之前的数值相比，卵巢储备功能有所改善：结果：与之前的数值相比，卵巢储备功能有所改善：FSH（13.57 vs. 11.32，p=0.11）、AMH（0.39 vs. 0.48，p=0.06）、前卵泡计数（3.98 vs. 5.75，pConclusions）：尽管是实验性的，但卵巢内 PRP 可恢复卵巢功能，对于卵巢储备功能低下且不接受卵母细胞捐献治疗的患者，可将其作为卵母细胞捐献的替代方案。目前还缺乏随机对照试验来支持这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Jornal Brasileiro de Reproducao Assistida OBSTETRICS & GYNECOLOGY-

CiteScore

3.30

自引率

6.70%

发文量