Cellulose nanocrystal/chitosan ratio in Pickering stabilizers regulates vitamin D3 release

IF 2.2 4区化学 Q3 CHEMISTRY, PHYSICAL

Colloid and Polymer Science Pub Date : 2024-06-03 DOI:10.1007/s00396-024-05273-8

Vasily I. Mikhaylov, Mikhail A. Torlopov, Irina N. Vaseneva, Ilia S. Martakov, Philipp V. Legki, Kirill A. Cherednichenko, Nikita M. Paderin, Petr A. Sitnikov

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Abstract

This study investigated the use of cellulose nanocrystals (CNC)/chitosan (Chit) polyelectrolyte complex as a stabilizing agent for Pickering emulsions. We demonstrated that chitosan reduces the surface charge of CNC improving the emulsification process. An optimal stabilizing complex containing 1% chitosan results in emulsions with minimal zeta potential (3.2 ± 0.3 mV), droplet size (2.8 ± 0.8 μm), and creaming index (19.8 ± 1.0%) values, along with high stability during storage, a change in pH, and high centrifugal forces (up to 2000 g). The study also showed that the maximum neutralized surface charge of the CNC in the CNC-Chit complex allows for effective adsorption on the surface of sunflower oil droplets, producing a denser stabilizing layer with a smaller droplet size. Additionally, chitosan addition is linked to improved stability and higher viscosity, with little dependence on ionic strength and temperature. Potentiometric titration revealed that compared with sulfated CNCs, five times less chitosan is needed to neutralize the negative surface charge of acetylated CNC. The wettability of a hydrophilic surface depends on the surface charge of the complex, and the wettability and adhesion performance increase with increasing chitosan content. Additionally, we showed that tuning the stabilizer composition can change the bioaccessibility of lipophilic compounds during oral administration.

Graphical Abstract

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皮克林稳定剂中纤维素纳米晶/壳聚糖的比例可调节维生素 D3 的释放

本研究调查了纤维素纳米晶体（CNC）/壳聚糖（Chit）聚电解质复合物作为皮克林乳剂稳定剂的使用情况。研究表明，壳聚糖可降低 CNC 的表面电荷，从而改善乳化过程。含有 1%壳聚糖的最佳稳定复合物可使乳液的 zeta 电位（3.2 ± 0.3 mV）、液滴大小（2.8 ± 0.8 μm）和起泡指数（19.8 ± 1.0%）值最小，同时在储存、pH 值变化和高离心力（高达 2000 g）条件下具有高稳定性。研究还表明，CNC-Chit 复合物中 CNC 的最大中和表面电荷可有效吸附在葵花籽油油滴表面，产生更致密的稳定层，油滴尺寸更小。此外，添加壳聚糖还能提高稳定性和粘度，而且与离子强度和温度的关系不大。电位滴定显示，与硫酸化 CNC 相比，中和乙酰化 CNC 表面负电荷所需的壳聚糖要少五倍。亲水性表面的润湿性取决于复合物的表面电荷，随着壳聚糖含量的增加，润湿性和粘附性能也会提高。此外，我们还发现，调整稳定剂的成分可以改变亲脂性化合物在口服过程中的生物可及性。

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来源期刊

Colloid and Polymer Science 化学-高分子科学

CiteScore

4.60

自引率

4.20%

发文量

111

审稿时长

2.2 months

期刊介绍： Colloid and Polymer Science - a leading international journal of longstanding tradition - is devoted to colloid and polymer science and its interdisciplinary interactions. As such, it responds to a demand which has lost none of its actuality as revealed in the trends of contemporary materials science.