Cytoplasmic mRNA Transport: Adaptors of mRNA Binding to Microtubule Motor Proteins

IF 1.5 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Biology Pub Date : 2024-06-05 DOI:10.1134/s0026893324700018

Y. A. Vdovina, S. G. Georgieva, D. V. Kopytova

引用次数: 0

Abstract

The process of mRNA localization in the cytoplasm involves the directed transport of mRNP particles using the microtubule system. This transport is mediated and regulated by specific factors—adaptors between mRNA molecules and microtubule motor proteins. Adaptors are a key link in the mechanism of mRNA transport, but to date their identity and functioning are mostly unknown. In this review, we examine the features and importance of adaptor proteins in mRNA transport during oogenesis and in neuronal function. This article summarizes recent data on mRNA binding adaptors in the cytoplasm and the mechanisms of their interaction with microtubule motor proteins.

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细胞质 mRNA 运输：mRNA 与微管运动蛋白结合的适配器

摘要 mRNA 在细胞质中的定位过程涉及 mRNP 颗粒利用微管系统的定向运输。这种运输是由特定因素介导和调控的，即 mRNA 分子和微管运动蛋白之间的适配体。适配体是 mRNA 运输机制中的关键环节，但迄今为止，它们的身份和功能大多不为人知。在这篇综述中，我们探讨了适配蛋白在卵子发生过程中的mRNA转运和神经元功能中的特征和重要性。本文总结了细胞质中 mRNA 结合适配体的最新数据，以及它们与微管马达蛋白的相互作用机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Biology 生物-生化与分子生物学

CiteScore

1.30

自引率

8.30%

发文量

审稿时长

3 months

期刊介绍： Molecular Biology is an international peer reviewed journal that covers a wide scope of problems in molecular, cell and computational biology including genomics, proteomics, bioinformatics, molecular virology and immunology, molecular development biology, molecular evolution and related areals. Molecular Biology publishes reviews, experimental and theoretical works. Every year, the journal publishes special issues devoted to most rapidly developing branches of physical-chemical biology and to the most outstanding scientists.