Head and neck melanoma: the eyelid region has a better prognosis and easier management. A retrospective survey and systematic review.

IF 1.5 4区 医学 Q3 DERMATOLOGY
Melanoma Research Pub Date : 2024-10-01 Epub Date: 2024-06-03 DOI:10.1097/CMR.0000000000000984
Federica Dini, Pietro Susini, Biancamaria Zuccaro, Giuseppe Nisi, Roberto Cuomo, Luca Grimaldi, Gabriella Perillo, Luca Tinunin, Pietro Antonini, Alessandro Innocenti, Giovanni Cecchi, Elisabetta Gambale, Laura Doni, Cinzia Mazzini, Nicola Santoro, Vincenzo De Giorgi
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引用次数: 0

Abstract

Eyelid melanoma (EM) is a malignant neoplasm accounting for around 1% of eyelid malignancies. Because of its rarity, most of our knowledge of EM is currently based on studies of cutaneous melanomas located elsewhere. Accordingly, this study aimed to specifically evaluate EM characteristics, management strategies, and prognosis. A retrospective study was carried out on patients diagnosed with EM at Careggi University Hospital, Florence between May 2012 and May 2022. In addition, a systematic review of relevant literature was conducted, encompassing studies published from 2013 to 2023. Clinical, histopathological, therapeutical, and prognostic data were analyzed to assess the metastasis rate and the 5-year survival rate of patients with EM. Separate data were extracted for in situ and invasive disease. Our original study included 19 patients diagnosed with EM with a 5-year survival rate of 100% for in situ and 83.3% for invasive EM. The literature review identified five poorly detailed large database reviews and 14 original studies on EM with an overall 5-year survival rate of 79.7%. The present research indicates that EM is a challenging malignancy, but has a relatively better prognosis and easier management than other melanomas of the head and neck region. These are probably related to the anatomical location which leads to early diagnosis. Therefore, EM should be considered as a specific disease requiring dedicated treatment. Based on the personal authors' experience and comprehensive overview of the current knowledge, a dedicated protocol is proposed.

头颈部黑色素瘤:眼睑区域预后较好且易于治疗:一项回顾性调查和系统性综述。
眼睑黑色素瘤(EM)是一种恶性肿瘤,约占眼睑恶性肿瘤的 1%。由于其罕见性,目前我们对EM的了解大多基于对其他部位皮肤黑色素瘤的研究。因此,本研究旨在专门评估EM的特征、治疗策略和预后。本研究对2012年5月至2022年5月期间在佛罗伦萨卡雷吉大学医院确诊的EM患者进行了回顾性研究。此外,还对 2013 年至 2023 年期间发表的相关研究文献进行了系统回顾。研究人员分析了临床、组织病理学、治疗和预后数据,以评估EM患者的转移率和5年生存率。原位和浸润性疾病的数据分别提取。我们最初的研究包括19名确诊为EM的患者,原位EM患者的5年生存率为100%,侵袭性EM患者的5年生存率为83.3%。文献综述发现了五篇不够详尽的大型数据库综述和14篇关于EM的原创研究,总体5年生存率为79.7%。目前的研究表明,EM是一种具有挑战性的恶性肿瘤,但与头颈部的其他黑色素瘤相比,其预后相对较好,治疗也相对容易。这可能与导致早期诊断的解剖位置有关。因此,EM 应被视为一种需要专门治疗的特殊疾病。根据作者的个人经验和对现有知识的全面了解,我们提出了一个专门的治疗方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Melanoma Research
Melanoma Research 医学-皮肤病学
CiteScore
3.40
自引率
4.50%
发文量
139
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Melanoma Research is a well established international forum for the dissemination of new findings relating to melanoma. The aim of the Journal is to promote the level of informational exchange between those engaged in the field. Melanoma Research aims to encourage an informed and balanced view of experimental and clinical research and extend and stimulate communication and exchange of knowledge between investigators with differing areas of expertise. This will foster the development of translational research. The reporting of new clinical results and the effect and toxicity of new therapeutic agents and immunotherapy will be given emphasis by rapid publication of Short Communications. ​Thus, Melanoma Research seeks to present a coherent and up-to-date account of all aspects of investigations pertinent to melanoma. Consequently the scope of the Journal is broad, embracing the entire range of studies from fundamental and applied research in such subject areas as genetics, molecular biology, biochemistry, cell biology, photobiology, pathology, immunology, and advances in clinical oncology influencing the prevention, diagnosis and treatment of melanoma.
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