Hungry for fat: Metabolic crosstalk with lipid-rich CAFs fuels pancreatic cancer

IF 27.7 1区生物学 Q1 CELL BIOLOGY

Cell metabolism Pub Date : 2024-06-04 DOI:10.1016/j.cmet.2024.05.007

Kostas A. Papavassiliou, Athanasios G. Papavassiliou

引用次数: 0

Abstract

Some cancers prefer to metabolize lipids for their growth and metastasis. In a recent Cancer Cell study, Niu et al. revealed that SET domain containing 2, histone lysine methyltransferase (SETD2)-deficient pancreatic cancer cells induce the differentiation of lipid-laden cancer-associated fibroblasts (CAFs), which, in turn, transport lipids to promote tumor growth.

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渴望脂肪与富含脂质的 CAFs 之间的代谢串扰助长了胰腺癌的发生

一些癌症喜欢代谢脂质以促进其生长和转移。在最近的一项《癌细胞》（Cancer Cell）研究中，Niu 等人发现，SET domain containing 2, histone lysine methyltransferase (SETD2) 缺陷的胰腺癌细胞会诱导富含脂质的癌相关成纤维细胞（CAFs）分化，进而运输脂质促进肿瘤生长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell metabolism 生物-内分泌学与代谢

CiteScore

48.60

自引率

1.40%

发文量

173

审稿时长

2.5 months

期刊介绍： Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.