Correlation between immunohistochemical staining and clinicopathological findings in endometrial carcinoma.

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Saudi Medical Journal Pub Date : 2024-06-01 DOI:10.15537/smj.2024.45.6.20230962

Samah N Saharti, Fadwa J Altaf

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引用次数: 0

Abstract

Objectives: To analyze the immunohistochemical staining pattern of mismatch repair (MMR) proteins and p53 in endometrial carcinoma cases, including different subtypes and stages, to gain insights into their role in the pathogenesis and clinical behaviour of this malignancy.

Methods: In this study, we investigate the association between MMR deficiency, p53 mutational status, and clinical outcomes in various subtypes of endometrial carcinoma. The immunohistochemical staining pattern of MMR proteins in 96 cases of endometrial carcinoma have been analyzed, including 72 endometrioid, 14 papillary serous, 5 clear cell, and 5 mixed Müllerian tumor.

Results: The results showed that 36 cases were MMR deficient, with the majority being of endometrioid subtype. The p53 immunostain showed a mutational pattern in a subset of cases, with a documented dismal prognosis. However, aforementioned stains failed to predict synchronous or metachronous cancers in 5 patients.

Conclusion: These findings highlight the importance of MMR and p53 immunohistochemical staining in the classification, and prognosis of endometrial carcinoma.

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子宫内膜癌免疫组化染色与临床病理结果的相关性。

研究目的分析不同亚型和分期子宫内膜癌病例中错配修复（MMR）蛋白和p53的免疫组化染色模式，以深入了解它们在这种恶性肿瘤的发病机制和临床表现中的作用：本研究探讨了不同亚型子宫内膜癌中 MMR 缺乏、p53 突变状态与临床预后之间的关联。分析了 96 例子宫内膜癌 MMR 蛋白的免疫组化染色模式，包括 72 例子宫内膜样癌、14 例乳头状浆液性癌、5 例透明细胞癌和 5 例混合型穆勒氏瘤：结果显示，36 例缺乏 MMR，其中大多数为子宫内膜样亚型。在一部分病例中，p53 免疫染色显示出突变模式，预后不良。然而，上述染色未能预测 5 例患者的同步或近交癌症：这些发现凸显了MMR和p53免疫组化染色在子宫内膜癌分类和预后中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Saudi Medical Journal 医学-医学：内科

CiteScore

2.30

自引率

6.20%

发文量

203

审稿时长

12 months

期刊介绍： The Saudi Medical Journal is a monthly peer-reviewed medical journal. It is an open access journal, with content released under a Creative Commons attribution-noncommercial license. The journal publishes original research articles, review articles, Systematic Reviews, Case Reports, Brief Communication, Brief Report, Clinical Note, Clinical Image, Editorials, Book Reviews, Correspondence, and Student Corner.