Fibrotic tumors tune metabolism for immune evasion

IF 23.5 1区医学 Q1 ONCOLOGY

Nature cancer Pub Date : 2024-06-03 DOI:10.1038/s43018-024-00758-5

Matthew D. Perricone, Costas A. Lyssiotis

引用次数: 0

Abstract

Tumor fibrosis is known to suppress anti-tumor immunity. A new study now highlights the role of tumor-associated macrophages in coordinating fibrosis-mediated metabolic changes in tumors, restricting cytotoxic T cell responses and contributing to tumor growth.

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纤维化肿瘤通过调整新陈代谢来逃避免疫。

众所周知，肿瘤纤维化会抑制抗肿瘤免疫。现在，一项新研究强调了肿瘤相关巨噬细胞在协调肿瘤纤维化介导的代谢变化、限制细胞毒性T细胞反应和促进肿瘤生长方面的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature cancer Medicine-Oncology

CiteScore

31.10

自引率

1.80%

发文量

129

期刊介绍： Cancer is a devastating disease responsible for millions of deaths worldwide. However, many of these deaths could be prevented with improved prevention and treatment strategies. To achieve this, it is crucial to focus on accurate diagnosis, effective treatment methods, and understanding the socioeconomic factors that influence cancer rates. Nature Cancer aims to serve as a unique platform for sharing the latest advancements in cancer research across various scientific fields, encompassing life sciences, physical sciences, applied sciences, and social sciences. The journal is particularly interested in fundamental research that enhances our understanding of tumor development and progression, as well as research that translates this knowledge into clinical applications through innovative diagnostic and therapeutic approaches. Additionally, Nature Cancer welcomes clinical studies that inform cancer diagnosis, treatment, and prevention, along with contributions exploring the societal impact of cancer on a global scale. In addition to publishing original research, Nature Cancer will feature Comments, Reviews, News & Views, Features, and Correspondence that hold significant value for the diverse field of cancer research.