Application value of a nano-siRNA delivery system in treatment against senile cataracts by modulating apoptosis in lens epithelial cells

Abstract

In this study, a novel nano-siRNA delivery system loaded with anti-ESR1 siRNA was designed. In a biological study, the new system was evaluated for the treatment and care of senile cataracts. The system significantly upregulated the expression level of the anti-apoptotic protein BCL-2, while significantly inhibiting the expression level of the inhibitory apoptotic protein BAX, thereby regulating apoptosis in lens epithelial cells. The system can be developed as a drug for the treatment of senile cataracts.