Chemical Composition, Antibacterial and Antifungal Potential of an Extract From the Leaves of Guapira Graciliflora Mart. Against Oral Microorganisms of Dental Interest

Pesquisa Brasileira em Odontopediatria e Clínica Integrada Pub Date : 2020-04-24 DOI:10.1590/pboci.2020.075

Thiara Karine de Araújo, E. M. M. D. B. Costa, C. Maia, P. Alves, C. Nonaka, Priscila Guimaraes Silva, Rennaly de Freitas Lima, G. Godoy

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Abstract

Objective: To perform an in vitro analysis of antibacterial and antifungal potential of an alcoholic extract from the leaves of Guapira Graciliflora Mart. against oral microorganisms and determine its chemical composition. Material and Methods: A hydroalcoholic extract of the leaves form G. graciliflora was obtained through maceration, vacuum concentration and freeze-drying. Antibacterial and antifungal activities were evaluated against Streptococcus mutans , Streptococcus salivarius , Streptococcus oralis , Streptococcus parasanguinis , Streptococcus mitis and strains of Candida albicans using broth microdilution method. Phytochemical analysis determined the total phenolic compounds, protein concentration and total of sugars present in the extract . Results: G. Graciliflora demonstrated antifungal activity against the LM 11 and LM 410 clinical isolates of C. albicans (MIC 0.5 mg/mL and 2 mg/mL, respectively). The other microorganisms tested were resistant to the extract. The phytochemical analysis revealed 3% proteins, 13% total sugars and 17% phenolic compounds . Conclusion: G. Graciliflora has antifungal activity against clinical strains of C. albicans and exhibits proteins, sugars and phenolic compounds in its chemical composition.

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Guapira Graciliflora Mart.叶提取物的化学成分、抗菌和抗真菌潜力抗牙科口腔微生物的潜力

目的对瓜蒌叶酒精提取物对口腔微生物的抗菌和抗真菌潜力进行体外分析，并确定其化学成分。材料与方法通过浸渍、真空浓缩和冷冻干燥获得了瓜皮拉叶的水醇提取物。采用肉汤微量稀释法，对变异链球菌、唾液链球菌、口腔链球菌、副咽炎链球菌、肝炎链球菌和白色念珠菌菌株的抗菌和抗真菌活性进行了评估。植物化学分析测定了提取物中的总酚类化合物、蛋白质浓度和总糖含量。结果G. Graciliflora 对 LM 11 和 LM 410 临床分离的白念珠菌具有抗真菌活性（MIC 分别为 0.5 毫克/毫升和 2 毫克/毫升）。测试的其他微生物对提取物具有抗性。植物化学分析显示，蛋白质占 3%，总糖占 13%，酚类化合物占 17%。结论G. Graciliflora 对白僵菌临床菌株具有抗真菌活性，其化学成分中含有蛋白质、糖类和酚类化合物。

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Pesquisa Brasileira em Odontopediatria e Clínica Integrada

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