Ruixin Deng, Xiaoqing Chen, Dongyan Zheng, Yuanyuan Xiao, Bilin Dong, Cunwei Cao, Lin Ma, Zhongsheng Tong, Min Zhu, Zehu Liu, Sha Lu, Meng Fu, Yun Jin, Bin Yin, Fuqiu Li, Xiaofang Li, Palida Abliz, Hongfang Liu, Yu Zhang, Nan Yu, Weiwei Wu, Xincai Xiong, Jingsi Zeng, Huaiqiu Huang, Yanping Jiang, Guanzhi Chen, Weihua Pan, Hong Sang, Ying Wang, Yun Guo, Dongmei Shi, Jianxun Yang, Yuping Ran, Jin Hu, Lianjuan Yang, Shuang Bai, Jin Yu, Xiaowen Wang, Ruoyu Li
{"title":"Epidemiologic features and therapeutic strategies of kerion: A nationwide multicentre study.","authors":"Ruixin Deng, Xiaoqing Chen, Dongyan Zheng, Yuanyuan Xiao, Bilin Dong, Cunwei Cao, Lin Ma, Zhongsheng Tong, Min Zhu, Zehu Liu, Sha Lu, Meng Fu, Yun Jin, Bin Yin, Fuqiu Li, Xiaofang Li, Palida Abliz, Hongfang Liu, Yu Zhang, Nan Yu, Weiwei Wu, Xincai Xiong, Jingsi Zeng, Huaiqiu Huang, Yanping Jiang, Guanzhi Chen, Weihua Pan, Hong Sang, Ying Wang, Yun Guo, Dongmei Shi, Jianxun Yang, Yuping Ran, Jin Hu, Lianjuan Yang, Shuang Bai, Jin Yu, Xiaowen Wang, Ruoyu Li","doi":"10.1111/myc.13751","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Kerion is a severe type of tinea capitis that is difficult to treat and remains a public health problem.</p><p><strong>Objectives: </strong>To evaluate the epidemiologic features and efficacy of different treatment schemes from real-world experience.</p><p><strong>Methods: </strong>From 2019 to 2021, 316 patients diagnosed with kerion at 32 tertiary Chinese hospitals were enrolled. We analysed the data of each patient, including clinical characteristics, causative pathogens, treatments and outcomes.</p><p><strong>Results: </strong>Preschool children were predominantly affected and were more likely to have zoophilic infection. The most common pathogen in China was Microsporum canis. Atopic dermatitis (AD), animal contact, endothrix infection and geophilic pathogens were linked with kerion occurrence. In terms of treatment, itraconazole was the most applied antifungal agent and reduced the time to mycological cure. A total of 22.5% of patients received systemic glucocorticoids simultaneously, which reduced the time to complete symptom relief. Furthermore, glucocorticoids combined with itraconazole had better treatment efficacy, with a higher rate and shorter time to achieving mycological cure.</p><p><strong>Conclusions: </strong>Kerion often affects preschoolers and leads to serious sequelae, with AD, animal contact, and endothrix infection as potential risk factors. Glucocorticoids, especially those combined with itraconazole, had better treatment efficacy.</p>","PeriodicalId":18797,"journal":{"name":"Mycoses","volume":"67 6","pages":"e13751"},"PeriodicalIF":4.1000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mycoses","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/myc.13751","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Kerion is a severe type of tinea capitis that is difficult to treat and remains a public health problem.
Objectives: To evaluate the epidemiologic features and efficacy of different treatment schemes from real-world experience.
Methods: From 2019 to 2021, 316 patients diagnosed with kerion at 32 tertiary Chinese hospitals were enrolled. We analysed the data of each patient, including clinical characteristics, causative pathogens, treatments and outcomes.
Results: Preschool children were predominantly affected and were more likely to have zoophilic infection. The most common pathogen in China was Microsporum canis. Atopic dermatitis (AD), animal contact, endothrix infection and geophilic pathogens were linked with kerion occurrence. In terms of treatment, itraconazole was the most applied antifungal agent and reduced the time to mycological cure. A total of 22.5% of patients received systemic glucocorticoids simultaneously, which reduced the time to complete symptom relief. Furthermore, glucocorticoids combined with itraconazole had better treatment efficacy, with a higher rate and shorter time to achieving mycological cure.
Conclusions: Kerion often affects preschoolers and leads to serious sequelae, with AD, animal contact, and endothrix infection as potential risk factors. Glucocorticoids, especially those combined with itraconazole, had better treatment efficacy.
期刊介绍：
The journal Mycoses provides an international forum for original papers in English on the pathogenesis, diagnosis, therapy, prophylaxis, and epidemiology of fungal infectious diseases in humans as well as on the biology of pathogenic fungi.
Medical mycology as part of medical microbiology is advancing rapidly. Effective therapeutic strategies are already available in chemotherapy and are being further developed. Their application requires reliable laboratory diagnostic techniques, which, in turn, result from mycological basic research. Opportunistic mycoses vary greatly in their clinical and pathological symptoms, because the underlying disease of a patient at risk decisively determines their symptomatology and progress. The journal Mycoses is therefore of interest to scientists in fundamental mycological research, mycological laboratory diagnosticians and clinicians interested in fungal infections.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
