Nucleic acid-responsive smart systems for controlled cargo delivery

IF 12.1 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biotechnology advances Pub Date : 2024-05-31 DOI:10.1016/j.biotechadv.2024.108393

Akbar Hasanzadeh , Arefeh Ebadati , Sara Saeedi , Babak Kamali , Hamid Noori , Behnam Jamei , Michael R. Hamblin , Yong Liu , Mahdi Karimi

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引用次数: 0

Abstract

Stimulus-responsive delivery systems allow controlled, highly regulated, and efficient delivery of various cargos while minimizing side effects. Owing to the unique properties of nucleic acids, including the ability to adopt complex structures by base pairing, their easy synthesis, high specificity, shape memory, and configurability, they have been employed in autonomous molecular motors, logic circuits, reconfigurable nanoplatforms, and catalytic amplifiers. Moreover, the development of nucleic acid (NA)-responsive intelligent delivery vehicles is a rapidly growing field. These vehicles have attracted much attention in recent years due to their programmable, controllable, and reversible properties. In this work, we review several types of NA-responsive controlled delivery vehicles based on locks and keys, including DNA/RNA-responsive, aptamer-responsive, and CRISPR-responsive, and summarize their advantages and limitations.

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用于控制货物运输的核酸响应智能系统。

刺激响应式输送系统可以控制、高度调节和高效地输送各种载体，同时最大限度地减少副作用。由于核酸的独特性质，包括通过碱基配对采用复杂结构的能力、易于合成、高特异性、形状记忆和可配置性，核酸已被用于自主分子马达、逻辑电路、可重构纳米平台和催化放大器。此外，核酸（NA）响应型智能运载工具的开发也是一个快速发展的领域。近年来，这些运载工具因其可编程、可控制和可逆的特性而备受关注。在这项工作中，我们回顾了几种基于锁和钥匙的核酸响应式可控运载工具，包括 DNA/RNA 响应式、aptamer 响应式和 CRISPR 响应式，并总结了它们的优势和局限性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biotechnology advances 工程技术-生物工程与应用微生物

CiteScore

25.50

自引率

2.50%

发文量

167

审稿时长

37 days

期刊介绍： Biotechnology Advances is a comprehensive review journal that covers all aspects of the multidisciplinary field of biotechnology. The journal focuses on biotechnology principles and their applications in various industries, agriculture, medicine, environmental concerns, and regulatory issues. It publishes authoritative articles that highlight current developments and future trends in the field of biotechnology. The journal invites submissions of manuscripts that are relevant and appropriate. It targets a wide audience, including scientists, engineers, students, instructors, researchers, practitioners, managers, governments, and other stakeholders in the field. Additionally, special issues are published based on selected presentations from recent relevant conferences in collaboration with the organizations hosting those conferences.