Ninety-Day Toxicological Assessment of Preparation of the Medicinal Plant Newbouldia laevis (P. Beauv.) Seem. (Bignoniaceae) in Rats

IF 1.5 4区医学 Q4 CHEMISTRY, MEDICINAL

Natural Product Communications Pub Date : 2024-05-29 DOI:10.1177/1934578x241257080

Akanji A. Murtala, Abidemi J. Akindele, Ibrahim A. Oreagba

{"title":"Ninety-Day Toxicological Assessment of Preparation of the Medicinal Plant Newbouldia laevis (P. Beauv.) Seem. (Bignoniaceae) in Rats","authors":"Akanji A. Murtala, Abidemi J. Akindele, Ibrahim A. Oreagba","doi":"10.1177/1934578x241257080","DOIUrl":null,"url":null,"abstract":"ObjectivesTo investigate the safety profile of subchronic oral administration of hydroethanol leaf extract of Newbouldia laevis (NL) in rats.MethodsNL was administered orally (20, 100, and 500 mg/kg) to groups of rats for 90 days. Distilled water served as control. Some rats were spared for an extra 30 days with no extract administration (reversibility study). Blood, urine and selected vital organs were collected for analyses.ResultsIn male rats, NL (20, 500 mg/kg) irreversibly increased ( P˂.05) bodyweight and feeding pattern with opposite trend of results in females. NL (20 mg/kg) elicited irreversible decrease ( P˂0.05) in RBC in male rats; a reversible decrease in RBC and Hb, and an irreversible increase (500 mg/kg) in WBC and neutrophils in females. In male rats, NL irreversibly decreased ( P˂.01) HDL-c and increased uric acid; in female rats, it elicited a reversible increase ( P˂.05, 500 mg/kg) in AST. NL (500 mg/kg) irreversibly decreased ( P˂.05) sperm motility and count, and produced an irreversible increase ( P˂.01) in testosterone levels in male rats (100 mg/kg). It reversibly decreased (20-500 mg/kg) luteinizing hormone levels (both sexes).ConclusionsNL is fairly safe at lower doses. However, it could cause anemia at lower doses, infertility (both sexes), liver and kidney injuries at high doses.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"25 1","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Communications","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/1934578x241257080","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

Abstract

ObjectivesTo investigate the safety profile of subchronic oral administration of hydroethanol leaf extract of Newbouldia laevis (NL) in rats.MethodsNL was administered orally (20, 100, and 500 mg/kg) to groups of rats for 90 days. Distilled water served as control. Some rats were spared for an extra 30 days with no extract administration (reversibility study). Blood, urine and selected vital organs were collected for analyses.ResultsIn male rats, NL (20, 500 mg/kg) irreversibly increased ( P˂.05) bodyweight and feeding pattern with opposite trend of results in females. NL (20 mg/kg) elicited irreversible decrease ( P˂0.05) in RBC in male rats; a reversible decrease in RBC and Hb, and an irreversible increase (500 mg/kg) in WBC and neutrophils in females. In male rats, NL irreversibly decreased ( P˂.01) HDL-c and increased uric acid; in female rats, it elicited a reversible increase ( P˂.05, 500 mg/kg) in AST. NL (500 mg/kg) irreversibly decreased ( P˂.05) sperm motility and count, and produced an irreversible increase ( P˂.01) in testosterone levels in male rats (100 mg/kg). It reversibly decreased (20-500 mg/kg) luteinizing hormone levels (both sexes).ConclusionsNL is fairly safe at lower doses. However, it could cause anemia at lower doses, infertility (both sexes), liver and kidney injuries at high doses.

查看原文本刊更多论文

药用植物 Newbouldia laevis (P. Beauv.) Seem.(Bignoniaceae）制剂对大鼠的九十天毒性评估

目的研究大鼠亚慢性口服牛肝菌（NL）水乙醇叶提取物的安全性。方法对各组大鼠连续 90 天口服牛肝菌叶提取物（20、100 和 500 毫克/千克）。蒸馏水作为对照组。部分大鼠在不服用提取物的情况下额外延长了 30 天（可逆性研究）。结果在雄性大鼠中，NL（20、500 毫克/千克）不可逆地增加了体重和摄食模式（P˂.05），而雌性大鼠的结果趋势相反。NL（20 毫克/千克）导致雄性大鼠的红细胞不可逆转地减少（P˂0.05）；雌性大鼠的红细胞和血红蛋白可逆地减少，白细胞和中性粒细胞不可逆转地增加（500 毫克/千克）。在雄性大鼠体内，NL 会不可逆地降低（P˂.01）高密度脂蛋白胆固醇并增加尿酸；在雌性大鼠体内，NL 会可逆地增加（P˂.05，500 毫克/千克）谷草转氨酶。NL （500 毫克/千克）会不可逆地降低（P˂.05）雄性大鼠（100 毫克/千克）的精子活力和数量，并不可逆地提高（P˂.01）睾酮水平。结论 NL 在较低剂量下相当安全。结论NL在较低剂量下相当安全，但在较低剂量下会导致贫血，在高剂量下会导致不育（雌雄均有）、肝脏和肾脏损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Natural Product Communications 工程技术-食品科技

CiteScore

3.10

自引率

11.10%

发文量

254

审稿时长

2.7 months

期刊介绍： Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products. Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products. Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products.