CAR Cells beyond Classical CAR T Cells: Functional Properties and Prospects of Application

IF 2.3 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Elizaveta P. Minina, Dmitry V. Dianov, Saveliy A. Sheetikov, Apollinariya V. Bogolyubova
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引用次数: 0

Abstract

Chimeric antigen receptors (CARs) are genetically engineered receptors that recognize antigens and activate signaling cascades in a cell. Signal recognition and transmission are mediated by the CAR domains derived from different proteins. T cells carrying CARs against tumor-associated antigens have been used in the development of the CAR T cell therapy, a new approach to fighting malignant neoplasms. Despite its high efficacy in the treatment of oncohematological diseases, CAR T cell therapy has a number of disadvantages that could be avoided by using other types of leukocytes as effector cells. CARs can be expressed in a wide range of cells of adaptive and innate immunity with the emergence or improvement of cytotoxic properties. This review discusses the features of CAR function in different types of immune cells, with a particular focus on the results of preclinical and clinical efficacy studies and the safety of potential CAR cell products.

Abstract Image

超越经典 CAR T 细胞的 CAR 细胞:功能特性与应用前景
摘要 嵌合抗原受体(CAR)是经基因工程改造的受体,可识别抗原并激活细胞内的信号级联。信号识别和传输由来自不同蛋白质的 CAR 结构域介导。携带针对肿瘤相关抗原的 CAR 的 T 细胞已被用于开发 CAR T 细胞疗法,这是一种对抗恶性肿瘤的新方法。尽管 CAR T 细胞疗法在治疗肿瘤疾病方面具有很高的疗效,但它也存在一些缺点,而使用其他类型的白细胞作为效应细胞则可以避免这些缺点。CAR 可在多种适应性免疫和先天性免疫细胞中表达,并具有或改善细胞毒性特性。本综述将讨论 CAR 在不同类型免疫细胞中的功能特点,尤其关注临床前和临床疗效研究的结果以及潜在 CAR 细胞产品的安全性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biochemistry (Moscow)
Biochemistry (Moscow) 生物-生化与分子生物学
CiteScore
4.70
自引率
3.60%
发文量
139
审稿时长
2 months
期刊介绍: Biochemistry (Moscow) is the journal that includes research papers in all fields of biochemistry as well as biochemical aspects of molecular biology, bioorganic chemistry, microbiology, immunology, physiology, and biomedical sciences. Coverage also extends to new experimental methods in biochemistry, theoretical contributions of biochemical importance, reviews of contemporary biochemical topics, and mini-reviews (News in Biochemistry).
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